研究概述：围绕脑功能相关疾病的发生机制，结合人群遗传学分析与动物模型研究，运用多组学测序、分子生物学及细胞生物学技术，从分子与细胞层面系统解析脑发育过程中神经发生、皮层结构建立及突触发育与可塑性的调控机制。

发表论文：

1.Peng X*, Jia X*, Wang H, Chen J, Zhang X, Tan S, Duan X, Qiu C, Hu M, Hou H, Parenti I, Kuechler A, Kaiser F J, Renck A, Caylor R, Skinner C, Peeden J, Cogne B, Isidor B, Mercier S, Nicolas G, Guerrot A M, Faletra F, Musante L, Cohen L, Bergant G, Cuturilo G, Peterlin B, Seeley A, Bachman K, Martinez-Agosto J A, van Ravenswaaij-Arts C, Bos D, Kim K H, Bartolomaeus T, Schmederer Z, Abou Jamra R, Aref-Eshghi E, Zhao W, Zou Y, Hu Z, Pan Q, Li F, Chen G, Li J, Hu Z, Xia K^#, Tan J^#, Guo H^#. Disrupting Integrator complex subunit INTS6 causes neurodevelopmental disorders and impairs neurogenesis and synapse development [J]. J Clin Invest, 2025, 135(22): e191729. （一作）

2.Duan X*, Peng X*, Jia X, Tan S, Guo H, Tan J, Hu Z^#. CELF2 Deficiency Demonstrates Autism-Like Behaviors and Interferes with Late Development of Cortical Neurons in Mice [J]. Mol Neurobiol, 2025, 62(1): 156–68. （一作）

3.Chen, C*., Peng, X*., Tang, J., Hu, Z., Tan, J. & Zeng, L. CDK5 inhibition protects against OGDR induced mitochondrial fragmentation and apoptosis through regulation of Drp1S616 phosphorylation[J]. Life Sci, 2021, 269:119062. （一作）

4.Si Z, Guan X, Teng X, Peng X, Wan Z, Li Q, Chen G, Tan J, Li J. Identification of CYP46A1 as a new regulator of lipid metabolism through CRISPR-based whole-genome screening. FASEB J. 2020 Oct;34(10):13776-13791.