研究概述：博士毕业于华东理工大学田禾院士团队，导师为赵春常教授与曲大辉教授（国家杰青）。主要从事智能荧光探针与分子光敏剂的构建及其在重大疾病领域（如脑部疾病、肿瘤等）的应用与转化研究。以药物化学、化学生物学等为基础，具体研究方向涉及a)生物医学成像与传感、b)分子影像与药物递送、c)多功能诊疗探针（如荧光、化学发光、诊疗一体化）的设计与应用。已发表SCI论文20余篇，其中以第一/通讯作者在 Aggregate, Sci. China Chem., J. Med. Chem., Anal. Chem.等国内外知名期刊上发表高水平论文7篇，其中中科院一区TOP论文6篇，获中国博士后科学基金会第 78 批面上资助。

招生专业/方向：生物学/神经生物学/化学/生物医学工程

发表论文：

1.Lixin Sun#, Hongyu Wu#, Ziwen Zhang, Kehuan Wu, Chunchang Zhao, Xianfeng Gu*, Da-Hui Qu*, A Smart Visualized Phototherapy Switch: from NIR-I Imaging-Guided Photodynamic Therapy to NIR-II Guided Photothermal Therapy for Enhanced Cascade Tumor Photoablation. Aggregate, 2025, 6, e70007.

2.Lixin Sun#, Huili Liu#, Zehua Qian, Ziwen Zhang, Hongyu Wu, Kehuan Wu, Nan Guo*, Da-Hui Qu*, Xianfeng Gu*, Chunchang Zhao, High-Fidelity Spatio-Temporal Recognition of Mitochondrial Esterase with an On-Demand Photoactivation Strategy. Sci. China Chem., 2025, 68, 3699-3706.

3.Lixin Sun, Xuemei Dong, Jinzhu Gao, Tianli Zhu, Jie Sun, Chengjun Dong, Rongchen Wang*, Xianfeng Gu*, Chunchang Zhao*, Precise Spatiotemporal Identification of Mitochondrial H₂S Fluctuations through Exploiting an On-Demand Photoactivated Probe. Anal. Chem., 2023, 95, 14288-14296.

4.Lixin Sun#, Zhecha Zheng#, Ziwen Zhang, Kehuan Wu, Hongyu Wu, Huili Liu, Mo Wang*, Chunchang Zhao, Xianfeng Gu*, Probing Deep Hydrogen Polysulfides Fluctuations in Vivo by Engineering Activatable Fluorescence Reporters with Second Near-Infrared Window Emission. Anal. Chem., 2024, 96, 20049-20056.

5.Lixin Sun#, Xinyu Wang#, Rui Chen#, Xuemei Dong, Jie Sun, Chengjun Dong, Haijiao Xie, Xianfeng Gu*, Chunchang Zhao*, Engineering organelle-specific activatable molecules for ultra-fast and reliable in situ mapping of subcellular nitric oxide. J. Mater. Chem. B, 2024, 12, 2304-2312.

6.Kehuan Wu#, Lixin Sun#, Hongyu Wu, Xinru Zheng, Yongxing Xue, Ziwen Zhang, Shaozong Ma, Chunchang Zhao, Yingchao Liu*, Xianfeng Gu*, H₂S-Activated Theranostic Platform for Precise Photoablation of Colorectal Tumors with NIR-II Dual-Modal Phototherapy. J. Med. Chem., 2025, 68, 24684-24700.

7.Zehua Qian#, Lixin Sun#, Rongchen Wang, Xuemei Dong, Jie Sun, Chengjun Dong, Da-Hui Qu, Xianfeng Gu*, Chunchang Zhao*, High-Fidelity Spatiotemporal Recognition of Golgi ALP through an Initial-Accumulation and Postactivation Strategy. Anal. Chem., 2024, 96, 9737-9743.

科研项目：

1.山东第一医科大学青年人才启动经费，2025-2030，主持

2.中国博士后科学基金面上资助项目，2025-2027，主持

3.国家自然科学基金面上项目，2023-2026，参与

专利：

1.赵春常，孙礼鑫，王荣晨，一种可按需光活化的用于线粒体H₂S实时成像的荧光探针及其制备与应用，CN116514855B

2.樊春海，诸颖，李江，焦凯，高越，孙礼鑫，刘霞，闫庆龙，一种溶酶体一氧化氮制剂及其制备方法与应用，CN119950743A