研究概述：长期从事于脑科学相关基础研究，重点关注大麻、酒精等精神活性物质与脑功能调控、躁郁症等精神疾病的致病机制探究等领域。（1）精神活性物质如大麻和酒精调控社会行为的神经环路及分子机制；（2）基于类脑器官模型的抑郁症和躁郁症等精神疾病的致病机制研究；（3）干细胞疗法的开发。

招生方向：生物学，基础医学等相关方向

发表论文：

1. Chonglei Fu^#, Xuehui Li^#, Xiaoxing Liu^#, Yongbo Zheng, Xiangxian Ma, Bo Zhang, Si Chen, Lingming Hu, Sizhen Su, Xiaokun Wang, Jie Sun, Qingqing Yin, Yumei Wang, Xiaolong Fu, Yanping Bao, Yanxue Xue, Lin Lu^*, Guichang Zou^*. Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease. Translational Neurodegeneration, 2025 Jul 25;14(1):38.

2. Ying-Han Wang^#, Chong-Lei Fu^#, Lin-Bo Chen^#, Chu-Yi Zhang, Jian-Shan Chen, Qiao-Ming Zhang, Yirui Liang, Rui-Lan Yang, Yu Li, Ya-Ni Zhang, Yi-Nuo Han, Zhen-Liang Yuan, Yi-Ni Chen, Haimei Li, Yanmeng Pan, Shaohua Hu, Ming Li^*, Li-Ping Cao^*, and Jun Yao^*. Microglia contributes to bipolar depression through Serinc2-dependent phospholipid synthesis, PNAS, 2025.

3. Jin Jin^#, Chonglei Fu^#, Jing Xia^#, Heyi Luo^#, Xianglian Wang, Si Chen, Huanhuan Mao, Kai Yuan, Lin Lu^*, Wei Xiong^*, Guichang Zou^*. Cannabidiol ameliorates cognitive decline in 5×FAD mouse model of Alzheimer’s disease through potentiating the function of extrasynaptic glycine receptors, Molecular Psychiatry, 2024, 10(12).

4. Wenlin Ren, Chonglei Fu, Yu Zhang, Xiaohui Ju, Xi Jiang, Jingwei Song, Mingli Gong, Zhuoyang Li, Wenchun Fan, Jun Yao, Qiang Ding^*. Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2, PNAS, 2024, 121(34): 1-12.

5. Siyao Lu, Chonglei Fu, Liang Liang, Bo Yang, Wei Shen, Qiuwen Wang, Yun Chen, Yanfen Chen, Yaonan Liu, Lin Zhu, Jieqing Zhao, Wei Shi, Shuangli Mi, Jun Yao^*. miR-218-2 regulates cognitive functions in the hippocampus through complement component 3-dependent modulation of synaptic vesicle release, PNAS, 2021, 118(14).

科研项目：

山东省博士后创新人才支持计划，山东省博士后创新项目，山东省高等学校青年创新团队项目

专利：

中脑类器官及其制备方法和在治疗帕金森病中的应用