研究概述：研究聚焦肠道菌与生殖健康、脑健康，以及荟萃分析（Meta-analysis）：主要围绕内分泌代谢、表观遗传、凋亡损伤等探究生殖系统发育疾病的发生机理，基于代谢组学、微生物学、转录组学、组织病理学等探究肠道健康与生殖健康、脑健康的分子机理，基于脑-体轴探究外周与中枢系统疾病的作用机制。

发表论文：

1.Yanan Hao, Xin Du, CHANG CAI, Yong Zhao and YongLin Ren^*. Ammonia (NH3) and hydrogen sulfide (H2S) -A new insights into gut microbiota and male infertility through meta-analysis. Frontiers in Cellular and Infection Microbiology, 2025 Jan 6; 14:1449453.（第一作者）

2.Hao Y^*, Feng Y^*, Yan X^*, Chen L^*, Ma X^*, Tang X, Zhong R, Sun Z, Agarwal M, Zhang H, Zhao Y. Gut Microbiota-Testis Axis: FMT Mitigates High-Fat Diet-Diminished Male Fertility via Improving Systemic and Testicular Metabolome. Microbiology Spectrum. 2022 Jun 29;10(3): e0002822.（第一作者）

3.Hao Y^*, Feng Y^*, Yan X^*, Chen L^*, Zhong R^*, Tang X, Shen W, Sun Q, Sun Z, Ren Y, Zhang H, Zhao Y. Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes. Molecular Medicine. 2022 Apr 25;28(1):45.（第一作者）

4.Yan X^*, Feng Y^*, Hao Y^*, Zhong R^*, Jiang Y^*, Tang X, Lu D, Fang H, Agarwal M, Chen L, Zhao Y, Zhang H. Gut-Testis Axis: Microbiota Prime Metabolome to Increase Sperm Quality in Young Type 2 Diabetes. Microbiology Spectrum. 2022 Oct 26;10(5): e0142322. （共一）

5.Hao Y, Fang H, Yan X, Shen W, Liu J, Han P, Zhao Y, Zhang W, Feng Y. Alginate Oligosaccharides Repair Liver Injury by Improving Anti-Inflammatory Capacity in a Busulfan-Induced Mouse Model. International Journal Molecular Sciences. 2023 Feb 4;24(4):3097.（第一作者）