研究概述：

采用多种分子等多种技术手段探究内耳前庭功能障碍的机制

发表论文：

1.Hu B^*, Wang N^*, Bi X^*, Karaaslan ES, Weber AL, Zhu W, Berendzen KW, Liu C. Plant lamin-like proteins mediate chromatin tethering at the nuclear periphery. Genome Biol. 2019 Apr 30;20(1):87.

2.Bi X, Liu C. Genome-Wide Identification of Chromatin Domains Anchored at the Nuclear Periphery in Plants. Methods Mol Biol. 2018;1830:381-393.

3.Bi XL^*, Cheng YJ^*, Hu B, Ma XL, Wu R, Wang JW, Liu C#. Nonrandom domain organization of the Arabidopsis genome at the nuclear periphery. Genome Research. 2017;27(7):1162-1173. Article

4.Bi X^*, Zhang J^*, Chen C, Zhang D, Li P^#, Ma F. Anthocyanin contributes more to hydrogen peroxide scavenging than other phenolics in apple peel. Food Chemistry. 2014;152:205-209. Article

5.Li P, Liu Z, Wang J, Bi X, Xiao Y, Qiao R, Zhou X, Guo S, Wan P, Chang M, Hong G, Liu Z, Ming X, Gao J^#, Fu X^#. Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice. FASEB J. 2022 Jun;36(6):e22373.

6.Hong G, Fu X, Chen X, Zhang L, Han X, Ding S, Liu Z, Bi X, Li W, Chang M, Qiao R, Guo S, Tu H, Chai R. Dyslexia-Related Hearing Loss Occurs Mainly through the Abnormal Spontaneous Electrical Activity of Spiral Ganglion Neurons. Adv Sci (Weinh). 2023 Jun;10(16):e2205754.

7.Fu X, Wan P, Lu L, Wan Y, Liu Z, Hong G, Cao S, Bi X, Zhou J, Qiao R, Guo S, Xiao Y, Wang B, Chang M, Li W, Li P, Zhang A, Sun J, Chai R, Gao J. Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels. Adv Sci (Weinh). 2023 Jul;10(20):e2300402.

8.Wang N, Wang Z, Tzourtzou S, Wang X, Bi X, Leimeister J, Xu L, Sakamoto T, Matsunaga S, Schaller A, Jiang H, Liu C. The plant nuclear lamina disassembles to regulate genome folding in stress conditions. Nat Plants. 2023 Jul;9(7):1081-1093.

主持课题：

国家自然科学基金，青年基金项目，RNA结合蛋白HuR介导的转录后调控在前庭毛细胞中的作用机制研究，2023-01至2025-12，30万；