研究概述：

①以生酮饮食干预癫痫相关机制为研究方向，深入探究在小鼠癫痫模型中生酮饮食防治癫痫的分子机制和神经机制。

②以调控免疫稳态防治中枢神经系统感染性疾病为方向，围绕细菌性脑膜炎中蛋白质的泛素化修饰和细胞焦亡机制探索药物作用机理。

发表论文：

1. Gao Z, Gao Y, Li Y, Zhou J, Li G, Xie S, Jia R, Wang L, Jiang Z, Liang M, Du C, Chen Y, Liu Y, Du L, Wang C, Dou S, Lv Z, Wang L, Wang R, Shen B, Wang Z, Li Y, Han G. 5-HT7R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination. J Adv Res. 2024 Mar 1:S2090-1232(24)00079-1.

2. Fan H^*, Gao Z^*, Ji K, Li X, Wu J, Liu Y, Wang X, Liang H, Liu Y, Li X, Liu P, Chen D, Zhao F. The in vitro and in vivo anti-inflammatory effect of osthole, the major natural coumarin from Cnidium monnieri (L.) Cuss, via the blocking of the activation of the NF-κB and MAPK/p38 pathways. Phytomedicine. 2019 May;58:152864.

3. Gao Z, Xie S, Wang L, Jiang L, Zhou J, Liang M, Li G, Wang Z, Li Y, Li Y, Han G. Hypidone hydrochloride (YL-0919) protects mice from meningitis via Sigma1R-STAT1-NLRP3-GSDMD pathway. Int Immunopharmacol. 2024 Feb 15;128:111524.

4. Li Y^*, Wang L^*, Gao Z^*, Zhou J, Xie S, Li G, Hou C, Wang Z, Lv Z, Wang R, Han G. Neuropeptide Calcitonin Gene-Related Peptide Promotes Immune Homeostasis of Bacterial Meningitis by Inducing Major Histocompatibility Complex Class II Ubiquitination. J Infect Dis. 2024 Mar 14;229(3):855-865.

5. Gao Z, Yu C, Liang H, Wang X, Liu Y, Li X, Ji K, Xu H, Yang M, Liu K, Qi D, Fan H. Andrographolide derivative CX-10 ameliorates dextran sulphate sodium-induced ulcerative colitis in mice: Involvement of NF-κB and MAPK signalling pathways. Int Immunopharmacol. 2018 Apr;57:82-90.