研究概述：采用细胞和动物模型结合行为学检测、分子和细胞生物学等技术研究脑衰老和神经退行性疾病的发病机制和早期干预措施。

发表论文：

1. Cai J^#, Chen Y^#, She Y, He X, Feng H, Sun H, Yin M, Gao J, Sheng C, Li Q, Xiao M. Aerobic exercise improves astrocyte mitochondrial quality and transfer to neurons in a mouse model of Alzheimer's disease. Brain Pathol. 2024 Oct 26:e13316.

2. Chen Y, He X, Cai J, Li Q. Functional aspects of the brain lymphatic drainage system in aging and neurodegenerative diseases. J Biomed Res. 2024 Mar 2;38(3):206-221. 

3. Feng H, Hu P, Chen Y, Sun H, Cai J, He X, Cao Q, Yin M, Zhang Y, Li Q, Gao J, Marshall C, Sheng C, Shi J, Xiao M. Decreased miR-451a in cerebrospinal fluid, a marker for both cognitive impairment and depressive symptoms in Alzheimer's disease. Theranostics. 2023 May 15;13(9):3021-3040.

4. Wang T^#, Chen Y^#, Zou Y, Pang Y, He X, Chen Y, Liu Y, Feng W, Zhang Y, Li Q, Shi J, Ding F, Marshall C, Gao J, Xiao M. Locomotor Hyperactivity in the Early-Stage Alzheimer's Disease-like Pathology of APP/PS1 Mice: Associated with Impaired Polarization of Astrocyte Aquaporin 4. Aging Dis. 2022 Oct 1;13(5):1504-1522.

5. Li Q^#, Chen Y^#, Feng W, Cai J, Gao J, Ge F, Zhou T, Wang Z, Ding F, Marshall C, Sheng C, Zhang Y, Sun M, Shi J, Xiao M. Drainage of senescent astrocytes from brain via meningeal lymphatic routes. Brain Behav Immun. 2022 Jul;103:85-96. 

主持课题：

1.国家自然科学基金，青年基金项目，2025-01至2027-12，30万；

2.山东省博士后创新人才支持计划项目，2023-9至2025-9，40万；

3.山东省博士后创新项目，2024-3至2025-12，3万。