研究概述:
主要通过行为学、神经示踪、光/化学遗传、群体/单细胞钙成像、神经电生理、免疫荧光染色等技术,从行为、环路、细胞、分子等层面探索癫痫、抑郁症等神经精神疾病的机制及其靶向调控。在相关领域发表论文20余篇,其中以第一作者或通讯作者身份发表论文8篇。参与多项国家自然科学基金重大仪器专项、面上项目及青年项目等。指导本科生完成多项大学生创新创业项目,并多次在各类大学生竞赛中获奖。
发表论文:
1.Dong L, Luan MY, Xing WY, Qi YN, Tian CX*, Zheng Y*. Micro-scale wireless electrical stimulation suppresses seizure-Like activity via GABAergic modulation in hippocampal slices[J]. Neuroscience, 2025, 586: 32–43.
2.Qi JB#, Suo XJ#, Tian CX#, et al. TESC overexpression reduces amyloid-β-induced hippocampal atrophy and memory decline[J]. Gene, 2025, 933:148939.
3.Zhao JY#, Wang YA#, Tian CX#, et al. Activating the astrocytes of the dorsal raphe nucleus via its neural circuits with the medial prefrontal cortex improves depression in mice[J]. Behavioural neurology, 2025, 8890705.
4.Dong L#, Qi YN#, Tian CX#, et al. A multi-channel implantable micro-magnetic stimulator for synergistic magnetic neuromodulation[J]. Brain research, 2025, 1860: 149679.
5.Dong L, Luan MY, Qi YN, Tian CX*, Zheng Y*. Calcium homeostasis restoration in pyramidal neurons through micrometer-scale wireless electrical stimulation in spinal cord injured mice[J]. Biochemical and biophysical research communications, 2024, 735:150487.
6.Tian CX#, Qi YN#, et al. Exploring the effect of arsenic-containing hydrocarbon on the bidirectional synaptic plasticity of the dorsal hippocampus[J]. International journal of molecular sciences, 2024, 25(13): 7223.
7.Cheng M#, Ye CH#, Tian CX#, et al. Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer's disease by neurotoxin neutralization and immune recognition suppression[J]. Bioactive materials 2023, 26: 337–352.
8.Zheng Y, Tian CX, Dong L, Tian L, Glabonjat R. A, Xiong C. Effect of arsenic-containing hydrocarbon on the long-term potentiation at Schaffer Collateral-CA1 synapses from infantile male rat[J]. Neurotoxicology, 2021, 84: 198–207.
9.Zhao DJ#, Tian C#, Cheng M, Yang F, Tian CX, et al. Carrier-free quercetin nanomedicine blocks NLRP3 deubiquitination and TXNIP recruitment for Parkinson’s disease therapy[J]. Chemical engineering journal, 2023, 464: 142697.
主持课题:
1.天津市研究生科研创新博士项目,2021YJSB275,THIP在成年雄性小鼠的抗抑郁作用机制研究,2021.10-2024.05,主持。
2.国家自然科学基金重大仪器专项,62027812,面向清醒动物脑科学研究的机器人化主动膜片钳系统,2021.01-2025.12,参与。
3.国家自然科学基金面上项目,62071329,植入式多通道微磁刺激装置设计及其对海马区Schaffer-CA1突触可塑性靶向性协同调控机制的研究,2021.01-2024.12,参与。
4.国家自然科学基金青年项目,62201383,无线植入式μMS设计及其对颞叶癫痫海马CA3区靶向性抑制机理的研究,2023.01-2025.12,参与。
5.国家科技创新2030-脑科学与类脑研究重大项目,2021ZD0202900,情感障碍类疾病分子网络与神经环路机制,2021.12-2026.11,参与。
6.航天医学实验领域项目,HYZHXM03003,长期在轨航天员睡眠问题对脑力疲劳的影响规律和对抗措施研究,2021.01-2024.12,参与。