研究概述：

基于虚拟筛选、分子动力学模拟和深度学习等技术筛选和设计靶向GPCR的药物。

发表论文：

1.Zhao Yang^#, Yu-Qi Ping^#, Ming-Wei Wang ^#, Chao Zhang ^#, Shu-Hua Zhou^#, Yue-Tong Xi#, Kong-Kai Zhu ^#, Wei Ding, Qi-Yue Zhang, Xiao Yu ^*, Peng Xiao^*, Fan Yi ^*, Ines Liebscher^*, Jin-Peng Sun^*. Identification, structure and agonist design of an androgen membrane receptor. Cell 2025 Jan 23:S0092-8674(25)00035-2.（共同一作）

2.Hui Lin^#, Chuanshun Ma^#, Kui Cai^#, Lulu Guo^#, Xuemei Wang^#, Lin Lv^#, Chao Zhang^#, Jun Lin^#, Daolai Zhang, Chuan Ye, Xiao Yu^*, Wei Kong^*, Changtao Jiang^* and Jin-Peng Sun^*. Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. Science. 2025 Mar 13:eado4188. （共同一作）

3.Zhang, C.; Zhang, R.; Qi, Y.; Wen, X.; Sun, J.; Xiao, P. Exploring the Binding Mechanism of ADGRG2 Through Metadynamics and Biochemical Analysis. Int. J. Mol. Sci. 2025, 26, 167. （独立一作）

4.Zheng Y^#, Jiang D^#, Lu Y^#, Zhang C^#, Huang SM^#, Lin H^#, Zhang D^#, Guo S^#, Han J, Chen J, He Y, Zhang M, Gao Y, Guo Y, Wei R, Xia M, Qin Y, Liu Z, Yang F, Ge S, Yi F, Yu X, Lin H, Xiao P, Sun JP, Feng S. Development of an allosteric adhesion GPCR nanobody with therapeutic potential. Nat Chem Biol. 2025 May 15.（共同一作）

5.Mao C^#, Xiao P^#, Tao XN^#, Qin J^#, He QT^#, Zhang C^#, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S^*, Yu X^*, Zhang Y^*, Sun JP^*. Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science. 2023 Apr 7;380(6640):eadd6220. (封面文章) （共同一作）

6.Chunyou Mao^#, Ru-Jia Zhao^#, Ying-Jun Dong^#, Mingxin Gao^#, Li-Nan Chen^#, Chao Zhang^#, Peng Xiao^#, Jia Guo, Jiao Qin, Dan-Dan Shen, Su-Yu Ji, Shao-Kun Zang, Huibing Zhang, Wei-Wei Wang, Qingya Shen, Jin-Peng Sun^*, Yan Zhang^*. Conformational transitions and activation of the adhesion receptor CD97, Molecular Cell. 2024,84; 3, （共同一作）

7.Shen-Ming Huang^#, Zhi-Zhen Huang^#, Lei Liu^#, Meng-Yao Xiong^#, Chao Zhang^#, Bo-Yang Cai^#, Ming-Wei Wang^#, Kui Cai, Ying-Li Jia, Jia-Le Wang, Ming-Hui Zhang, Yi-He Xie, Min Li, Hang Zhang, Cheng-Hao Weng, Xin Wen, Zhi Li, Ying Sun. et al. Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters. Nat Commun 15, 10226 (2024) （共同一作）

8.Fan Yang^#, Lulu Guo^#, Yu Li^#, Guopeng Wang^#, Jia Wang^#, Chao Zhang^#, Guo-Xing Fang, Xu Chen, Lei Liu, Xu Yan, Qun Liu, Changxiu Qu, Yunfei Xu, Peng Xiao, Zhongliang Zhu, Zijian Li, Jiuyao Zhou, Xiao Yu, Ning Gao^* & Jin-Peng Sun^*. Structure, function and pharmacology of human itch receptor complexes. Nature 600, 164–169 (2021). （共同一作）