研究概述：

主要从事智能荧光探针与分子光敏剂的构建及其在重大疾病领域（如脑部疾病、肿瘤等）的应用研究。以药物化学、化学生物学等为基础，具体研究方向涉及a)生物医学成像与传感、b)分子影像与药物递送、c)多功能诊疗探针（如荧光、化学发光、诊疗一体化）的设计与应用。

发表论文：

1.Lixin Sun^#, Hongyu Wu^#, Ziwen Zhang, Kehuan Wu, Chunchang Zhao^*, Xianfeng Gu^*, Da-Hui Qu^*, A Smart Visualized Phototherapy Switch: from NIR-I Imaging-Guided Photodynamic Therapy to NIR-II Guided Photothermal Therapy for Enhanced Cascade Tumor Photoablation. Aggregate, 2025, 6, e70007.

2.Lixin Sun^#, Huili Liu^#, Zehua Qian, Ziwen Zhang, Hongyu Wu, Kehuan Wu, Nan Guo^*, Da-Hui Qu^*, Xianfeng Gu^*, Chunchang Zhao, High-Fidelity Spatio-Temporal Recognition of Mitochondrial Esterase with an On-Demand Photoactivation Strategy. Sci. China Chem., 2025, 68, 3699-3706.

3.Lixin Sun, Xuemei Dong, Jinzhu Gao, Tianli Zhu, Jie Sun, Chengjun Dong, Rongchen Wang^*, Xianfeng Gu^*, Chunchang Zhao^*, Precise Spatiotemporal Identification of Mitochondrial H₂S Fluctuations through Exploiting an On-Demand Photoactivated Probe. Anal. Chem., 2023, 95, 14288-14296.

4.Lixin Sun^#, Zhecha Zheng^#, Ziwen Zhang, Kehuan Wu, Hongyu Wu, Huili Liu, Mo Wang^*, Chunchang Zhao, Xianfeng Gu^*, Probing Deep Hydrogen Polysulfides Fluctuations in Vivo by Engineering Activatable Fluorescence Reporters with Second Near-Infrared Window Emission. Anal. Chem., 2024, 96, 20049-20056.

5.Lixin Sun^#, Xinyu Wang^#, Rui Chen^#, Xuemei Dong, Jie Sun, Chengjun Dong, Haijiao Xie, Xianfeng Gu^*, Chunchang Zhao^*, Engineering organelle-specific activatable molecules for ultra-fast and reliable in situ mapping of subcellular nitric oxide. J. Mater. Chem. B, 2024, 12, 2304-2312.

6.Zehua Qian^#, Lixin Sun^#, Rongchen Wang, Xuemei Dong, Jie Sun, Chengjun Dong, Da-Hui Qu, Xianfeng Gu^*, Chunchang Zhao^*, High-Fidelity Spatiotemporal Recognition of Golgi ALP through an Initial-Accumulation and Postactivation Strategy, Anal. Chem., 2024, 96, 9737-9743.

7.Xuemei Dong, Lixin Sun, Ziwen Zhang, Tianli Zhu, Jie Sun, Jinzhu Gao, Chengjun Dong, Rongchen Wang^*, Xianfeng Gu^*, Chunchang Zhao^*, A dual-modality hydrogen sulfide-specific probe integrating chemiluminescence with NIR fluorescence for targeted cancer imaging. Sci. China Chem., 2023, 66, 1869-1876.