研究概述：从事于精神活性物质与脑功能调控、抑郁症和躁郁症等精神疾病的致病机制研究、基于干细胞和脑类器官模型的细胞疗法开发等。

发表论文：

1.Chonglei Fu^#, Xuehui Li^#, Xiaoxing Liu^#, Yongbo Zheng, Xiangxian Ma, Bo Zhang, Si Chen, Lingming Hu, Sizhen Su, Xiaokun Wang, Jie Sun, Qingqing Yin, Yumei Wang, Xiaolong Fu, Yanping Bao, Yanxue Xue, Lin Lu*, Guichang Zou*. Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease. Translational Neurodegeneration, 2025 Jul 25;14(1):38.

2.Ying-Han Wang^#, Chong-Lei Fu^#, Lin-Bo Chen^#, Chu-Yi Zhang, Jian-Shan Chen, Qiao-Ming Zhang, Yirui Liang, Rui-Lan Yang, Yu Li, Ya-Ni Zhang, Yi-Nuo Han, Zhen-Liang Yuan, Yi-Ni Chen, Haimei Li, Yanmeng Pan, Shaohua Hu, Ming Li*, Li-Ping Cao*, and Jun Yao*. Microglia contributes to bipolar depression through Serinc2-dependent phospholipid synthesis, PNAS, 2025.

3.Jin Jin^#, Chonglei Fu^#, Jing Xia^#, Heyi Luo^#, Xianglian Wang, Si Chen, Huanhuan Mao, Kai Yuan, Lin Lu*, Wei Xiong* and Guichang Zou*. Cannabidiol ameliorates cognitive decline in 5×FAD mouse model of Alzheimer's disease through potentiating the function of extrasynaptic glycine receptors, Molecular Psychiatry, 2024, doi: 10.1038/s41380-024- 02789-x.

4.Wenlin Ren, Chong-Lei Fu, Yu Zhang Y, Xiaohui Ju, Xi Jiang, Jingwei Song, Mingli Gong, Zhuoyang Li, Wenchun Fan, Jun Yao, Qiang Ding. Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2. PNAS. 2024 Aug 20;121(34):e2403235121.

5.Chong-Lei Fu, Bo-Cheng Dong, Xi Jiang, Dan Li, and Jun Yao. A cell therapy approach based on iPSC-derived midbrain organoids for the restoration of motor function in a Parkinson's disease mouse model. Heliyon. 2024 Jan 9;10(2):e24234.

6.Chonglei Fu, Xi Jiang, Bocheng Dong, Dan Li, Xinyu She, Jun Yao*. Protocol for transplantation of cells derived from human midbrain organoids into a Parkinson’s disease mouse model to restore motor function, STAR Protocols, 2024, 5(103251).

7.Si-Yao Lu, Chong-Lei Fu, Liang Liang, Bo Yang, Wei Shen, Qiu-Wen Wang, Yun Chen, Yan-Fen Chen, Yao-Nan Liu, Lin Zhu, Jieqing Zhao, Wei Shi, Shuangli Mi, and Jun Yao. miR-218-2 regulates cognitive functions in the hippocampus through complement component 3-dependent modulation of synaptic vesicle release. PNAS. 2021 Apr 6;118(14):e2021770118.

8.Chong-Lei Fu, Xian-Feng Wang, Qian Cheng, Dan Wang, Susumu Hirose and Qing-Xin Liu. The T-box transcription factor Midline regulates wing development by repressing wingless and hedgehog in Drosophila. Sci Rep. 2016 Jun 15; 6: 27981.