研究概述：研究聚焦肠道菌与生殖健康、脑健康，以及荟萃分析（Meta-analysis）：主要围绕内分泌代谢、表观遗传、凋亡损伤等探究生殖系统发育疾病的发生机理，基于代谢组学、微生物学、转录组学、组织病理学等探究肠道健康与生殖健康、脑健康的分子机理，基于神经环路等探究外周与中枢系统疾病的机制。
发表论文：
1.Yanan Hao, Xin Du, CHANG CAI, Yong Zhao and YongLin Ren*. Ammonia (NH3) and hydrogen sulfide (H2S) -A new insights into gut microbiota and male infertility through meta-analysis. Frontiers in Cellular and Infection Microbiology, 2025 Jan 6; 14:1449453.
2.Hao Y*, Feng Y*, Yan X*, Chen L*, Ma X*, Tang X, Zhong R, Sun Z, Agarwal M, Zhang H, Zhao Y. Gut Microbiota-Testis Axis: FMT Mitigates High-Fat Diet-Diminished Male Fertility via Improving Systemic and Testicular Metabolome. Microbiology Spectrum. 2022 Jun 29;10(3): e0002822.
3.Hao Y*, Feng Y*, Yan X*, Chen L*, Zhong R*, Tang X, Shen W, Sun Q, Sun Z, Ren Y, Zhang H, Zhao Y. Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes. Molecular Medicine. 2022 Apr 25;28(1):45.
4.Yan X*, Feng Y*, Hao Y*, Zhong R*, Jiang Y*, Tang X, Lu D, Fang H, Agarwal M, Chen L, Zhao Y, Zhang H. Gut-Testis Axis: Microbiota Prime Metabolome to Increase Sperm Quality in Young Type 2 Diabetes. Microbiology Spectrum. 2022 Oct 26;10(5): e0142322.
5.Hao Y, Fang H, Yan X, Shen W, Liu J, Han P, Zhao Y, Zhang W, Feng Y. Alginate Oligosaccharides Repair Liver Injury by Improving Anti-Inflammatory Capacity in a Busulfan-Induced Mouse Model. International Journal Molecular Sciences. 2023 Feb 4;24(4):3097.
6.Hao Y, Zhang H, Zhang P, Yu S, Ma D, Li L, Feng Y, Min L, Shen W, Zhao Y. Chlorothalonil inhibits mouse ovarian development through endocrine disruption. Toxicology Letters. 2019 Mar 15;303: 38-47.
7.Hao Y*, Liu J*, Feng Y, Yu S, Zhang W, Li L, Min L, Zhang H, Shen W, Zhao Y. Molecular evidence of offspring liver dysfunction after maternal exposure to zinc oxide nanoparticles. Toxicology and Applied Pharmacology. 2017 Aug 15;329: 318-325.
8.Zhang P, Feng Y, Li L, Ge W, Yu S, Hao Y, Shen W, Han X, Ma D, Yin S, Tian Y, Min L, Sun Z, Sun Q, Zhang H, Zhao Y. Improvement in sperm quality and spermatogenesis following faecal microbiota transplantation from alginate oligosaccharide dosed mice. Gut. 2021 Jan;70(1):222-225.
