研究概述：利用细胞、分子生物学等技术手段，从体内外水平研究帕金森等神经退行性疾病的发病、生物节律紊乱、睡眠障碍相关的机制。
发表论文：
1. Jia C*, Tian L*, Cheng C, Zhang J, Al-Nusaif M, Li T, Yang H, Lin Y, Li S, Le W. α-Synuclein reduces acetylserotonin O-methyltransferase mediated melatonin biosynthesis by microtubule-associated protein 1 light chain 3 beta-related degradation pathway. Cell Mol Life Sci. 2024 Jan 27;81(1):61.
2. Li T*, Jia C*, Le W. Hypocretin neuron hyperexcitability in the hypothalamus: a newly discovered culprit in aging-related sleep impairment. Signal Transduct Target Ther. 2022 Jul 15;7(1):236.
3. Jia C, Cheng C, Li T, Chen X, Yang Y, Liu X, Li S, Le W. α-Synuclein Up-regulates Monoamine Oxidase A Expression and Activity via Trans-Acting Transcription Factor 1. Front Aging Neurosci. 2021 Mar 17;13:653379.
4. Li S*, Jia C*, Li T, Le W. Hot Topics in Recent Parkinson's Disease Research: Where We are and Where We Should Go. Neurosci Bull. 2021 Dec;37(12):1735-1744.
5. Jia C, Qi H, Cheng C, Wu X, Yang Z, Cai H, Chen S, Le W. α-Synuclein Negatively Regulates Nurr1 Expression Through NF-κB-Related Mechanism. Front Mol Neurosci. 2020 May 12;13:64.
6. Jia CC*, Li G*, Jiang R, Liu X, Yuan Q, Le W, Hou Y, Wang B. B-Cell Receptor-Associated Protein 31 Negatively Regulates the Expression of Monoamine Oxidase A Via R1. Front Mol Biosci. 2020 Apr 30;7:64.
7. Xu H, Jia C, Cheng C, Wu H, Cai H, Le W. Activation of autophagy attenuates motor deficits and extends lifespan in a C. elegans model of ALS. Free Radic Biol Med. 2022 Mar;181:52-61.
8. Li T, Tan X, Tian L, Jia C, Cheng C, Chen X, Wei M, Wang Y, Hu Y, Jia Q, Ni Y, Al-Nusaif M, Li S, Le W. The role of Nurr1-miR-30e-5p-NLRP3 axis in inflammation-mediated neurodegeneration: insights from mouse models and patients' studies in Parkinson's disease. J Neuroinflammation. 2023 Nov 22;20(1):274.
9. Liu X, Jiao K, Jia CC, Li GX, Yuan Q, Xu JK, Hou Y, Wang B. BAP31 regulates IRAK1-dependent neuroinflammation in microglia. J Neuroinflammation. 2019 Dec 28;16(1):281.
主持课题：
1.山东省自然科学基金青年项目，帕金森病重要基因Nurr1通过生物钟基因Clock调控睡眠的机制研究，2025-01至2027-12，12万；
2.国家自然科学基金委员会,青年科学基金项目,突触核蛋白α-synuclein通过核激素受体Nr1d1调控帕金森睡眠障碍的机制研究, 2022-01至2024-12,30万元
