研究概述：聚焦于神经调控干预重大神经精神疾病的技术开发及应用，综合运用侵入式和非侵入式神经调控、神经电生理、神经影像、机器学习算法等多学科交叉手段，探索抑郁障碍、认知障碍等重大神经精神疾病的心理-神经表征，开发精准干预的神经调控技术并实现临床转化，具体研究方向如下：1. 神经调控技术调控大脑的生物-物理效应；2. 重大神经精神疾病的心理-神经表征;3. 神经调控技术干预重大神经精神疾病的机制。

发表论文：

1.Wang ZY, Jiang C, Guan LX, Zhao L, Fan TT, Wang J, Cai XD, Zhang YL, Yao C, Peng B, Wang FX, Hu CH, Cui ZQ^#, Tu YH^#, Li LM^#. Deep brain stimulation of habenula reduces depressive symptoms and modulates brain activities in treatment-resistant depression. Nature Mental Health. 2024, 2: 1045-1052.

2.Cheng TY^*, Hu YB^*, Qin XY, Ma JY, Zha DQ, Xie H, Ji TY, Liu QZ, Wang ZY^#, Wu Y^#, Hao HW^#, Li LM. A Predictive Model Combining Connectomics and Entropy Biomarkers to Discriminate Long-term Vagus Nerve Stimulation Efficacy for Pediatric Patients with Drug-Resistant Epilepsy. CNS Neuroscience & Therapeutics. 2024, 30(7):e14751. 

3.Guo XJ^*, Lei CS^*, Liang HW^*, Fang YB, An JX, Zhang XL, Wang ZY^#, Hu CH, Jiang X^#. Chronic Sacral Nerve Stimulation Inhibits Visceral Hypersensitivity in Diarrhea-Predominant Irritable Bowel Syndrome Rats Model. Neuromodulation. 2023, 27(2):295-301. 

4.Zhang YQ, Ma LY, Zhang XY, Yue LP, Wang JX, Zheng J, Cui S, Liu FY, Wang ZY^#, Wan Y^#, Yi M^#.  Deep brain stimulation in the lateral habenula reverses local neuronal hyperactivity and ameliorates depression-like behaviors in rats. Neurobiol Dis, 2023, 180:106069.

5.Cui ZQ, Jiang C, Hu CH, Tian Y, Ling ZP, Wang J, Fan TT, Hao HW, Wang ZY^#, Li LM^#. Safety and precision of frontal trajectory of lateral habenula deep brain stimulation surgery in treatment-resistant depression. Front. Neurol. 2023, 14: 1113545.

6.Ma JY^*, Wang ZY^*, Cheng TY, Hu YB, Qin XY, et al. A prediction model integrating synchronization biomarkers and clinical features to identify responders to vagus nerve stimulation among pediatric patients with drug-resistant epilepsy. CNS Neuroscience & Therapeutics. 2022, 28(11): 1838-1848. 

7.Wang ZY^*, Yuan X^*, Zhang Q, Wen JL, Cheng TY, Qin XY, Ji T, Shu X, Jiang Y, Liao JX, Hao HW, Li LM^#, Wu Y^#. Effects of stable vagus nerve stimulation efficacy on autistic behaviors in ten pediatric patients with drug resistant epilepsy: an observational study. Front Pediatrics. 2022, 10:846301. 

8.Wang ZY^*, Cai XD^*, Qiu RR, Yao C, Tian Y, Gong C, Zhang YL, Xu B, Zhang DD, Zang YL^#, Liu JL, Peng B, Li LM^#. Case Report: Lateral Habenula Deep Brain Stimulation for Treatment-Resistant Depression. Front Psychiatry. 2021, 11:616501.  

9.Wang ZY, Yue LP, Cui CL^#, Liu SL, Wang XW, Li YJ, Ma LY. Top-down control of the medial orbitofrontal cortex to nucleus accumbens core pathway in decisional impulsivity. Brain Struct Funct. 2019, 224(7):2437-2452.

10.Wang ZY, Liang SX, Yu SS, Xie T, Wang BC, Wang J, Li YJ, Shan BC, Cui CL^#. Distinct Roles of Dopamine Receptors in the Lateral Thalamus in a Rat Model of Decisional Impulsivity. Neurosci Bull. 2017, 33(4):413-422.