研究概述：
1.生物钟基因（CLOCK）作为转录调控因子，调节着上千下游基因的表达。我们的研究聚焦于生物钟相关基因与神经系统疾病的发病机制；
2.早产儿因为缺氧引发脑白质损伤，主要在于少突胶质细胞前体细胞（OPC）的分化与成熟受到影响，从而影响了脑白质的髓鞘化进程。我们研究影响OPC的分化成熟机理以及脑白质损伤的修复机制；
3.发育性神经系统疾病致病基因（DCX、DEAF1、CNNM2等）的分子机制和治疗新途径的研究和探索。
发表论文：
1. Deng L, Jiang H, Lin J, Xu D, Qi A, Guo Q, Li PP,，Wang X, Liu JS#, Fu X#, Li P#. Clock knockout in inhibitory neurons reduces predisposition to epilepsy and influences anxiety-like behaviors in mice. Neurobiol Dis. 2024 Apr;193:106457.
2. Ping He, Dongyan Zhou, Shuangya Chen, Shuting Zhong, Zhiyan Xia, Di Xu, Xiaokun Li, Peijun Li#, Cong Wang#, FGF is required for Purkinje cell development and function in the crebellum, iScience 2024 Jan 26;27(2):109039.
3. Li L, Su Y, Wang S, Wang C, Ruan N, Hu Z, Cheng X, Chen J, Yuan K, Li P#, Fan P#. Neonatal di-(2-ethylhexyl)phthalate exposure induces permanent alterations in secretory CRH neuron characteristics in the hypothalamus paraventricular region of adult male rats. Exp Neurol. 2024 Feb;372:114616.
4. Wang M*, Li P*, Li Z*, da Silva BS, Zheng W, Xiang Z, He Y, Xu T, Cordeiro C, Deng L, Dai Y, Ye M, Lin Z, Zhou J, Zhou X, Ye F, Cunha RA, Chen J, Guo W. Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula. Nat Commun. 2023 Apr 5;14(1):1880.
5. Shang H*, Li P*, Lin X, Cai Q, Li Z, Deng L, Song Y, Chen JF, Zhou J. Neuronal and astrocytic CB1R signaling differentially modulates goal-directed behavior and working memory by distinct temporal mechanisms. Neuropsychopharmacology. 2023 Sep;48(10):1520-1531.
6. Li X, Qiu W, Deng L, Lin J, Huang W, Xu Y, Zhang M, Jones NC, Lin R, Xu H, Lin L, Li P#, Wang X#. 11β-HSD1 participates in epileptogenesis and the associated cognitive impairment by inhibiting apoptosis in mice. J Transl Med. 2022 Sep 5;20(1):406.
7. Li P*#, Fu X*, Smith NA, Ziobro J, Curiel J, Tenga MJ, Martin B, Freedman S, Cea-Del Rio CA, Oboti L, Tsuchida TN, Oluigbo C, Yaun A, Magge SN, O'Neill B, Kao A, Zelleke TG, Depositario-Cabacar DT, Ghimbovschi S, Knoblach S, Ho CY, Corbin JG, Goodkin HP, Vicini S, Huntsman MM, Gaillard WD, Valdez G, Liu JS. Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy. Neuron. 2017 Oct 11;96(2):387-401.e6.
8. Zonouzi M, Scafidi J, Li P, McEllin B, Edwards J, Dupree JL, Harvey L, Sun D, Hübner CA, Cull-Candy SG, Farrant M, Gallo V. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nat Neurosci. 2015 May;18(5):674-82.
9. Mangin JM, Li P, Scafidi J, Gallo V. Experience-dependent regulation of NG2 progenitors in the developing barrel cortex. Nat Neurosci. 2012 Sep;15(9):1192-4.
10. Li P, Rudolph U, Huntsman MM. Long-term sensory deprivation selectively rearranges functional inhibitory circuits in mouse barrel cortex. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12156-61.
主持课题：
国家自然科学基金，面上项目，神经元与少突胶质前体细胞在早产儿缺氧性脑损伤复中的参与机理，2021-01至2024-12；
