研究概述: 神经精神性疾病发病机制及治疗药物研究

发表论文：

1.Lin Z, Huang L, Cao Q, Luo H, Yao W^*, Zhang JC^*. Inhibition of abnormal C/EBPβ/α-Syn signaling pathway through activation of Nrf2 ameliorates Parkinson's disease-like pathology. Aging cell. 2023, 23: e13958.

2.Yao W^#, Cao QQ^#, Luo SL^#, He LJ, Yang C, Chen JX, Qi Q^*, Hashimoto K^*, and Zhang JC^*. Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine. Mol Psychiatry. 2022, 27(3): 1618–1629.

3.He L^#, Zheng Y^#, Huang L^#, Ye J, Ye Y, Luo H, Chen X, Yao W^*, Chen J^*, Zhang JC^*. Nrf2 regulates the arginase 1⁺ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice. Transl Psychiatry. 2022,12(1): 459.

4.Zhang JC^*, Yao W, and Hashimoto K^*. Arketamine, a new rapid-acting antidepressant: A historical review and future directions. Neuropharmacology. 2022. 218:109219.

5.Cao QQ ^#, Luo SL^#, Yao W^#, Qu YG, Wang NB, Hong J, Murayama S, Zhang ZT, Chen JX, Hashimoto K^*, Qi Qi^*, and Zhang JC^*. Suppression of abnormal a-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology. Molecular Therapy Nucleic Acids. 2022, 29: 1-15.

6.Cao QQ^#, Zou QM^#, Zhao X^#, Zhang YM^#, Qu YG, Wang NB, Murayama S, Qi Q, Hashimoto K^*, Lin S^*, Zhang JC^*. Regulation of BDNF transcription by Nrf2 and MeCP2 ameliorates MPTP-induced neurotoxicity. Cell Death Discov. 2022, 8(1):267.

7.Tang R^#, Cao QQ^#, Hu SW^#, He LJ, Du PF, Chen G, Fu R, Xiao F, Sun YR^*, Zhang JC^* and Qi Q^*. Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription. Acta Pharmacologica Sinica. 2022, 43, 829-839.

8.Yao W^#, Lin S^#, Su J, Cao QQ, Chen YY, Chen JX, Zhang ZT, Hashimoto K^*, Qi Q^* and Zhang JC^*. Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents. Transl Psychiatry. 2021, 11: 140.

9.Asada K, Sakaue F, Nagata T, Zhang JC, Yoshida-Tanaka K, Abe A, Nawa M, Nishina K, Yokota T^*. Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing. Nucleic Acids Res. 2021 May 21;49(9):4864-4876

10.Xia Y, Wang ZH, Zhang JC, Liu X, Yu SP, Ye KX, Wang JZ, Ye K, Wang XC. C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease. Mol Psychiatry. 2021, 26(10): 6002-6022.

主持课题：

1.国家自然科学基金，面上项目，R-氯胺酮通过CREB/MeCP2调节BDNF转录翻译发挥强效而持久抗抑郁作用的机制研究，2023-01-2026-12

2.山东省自然科学基金，重大基础研究项目，基于宏观尺度脑网络的帕金森病核心环路研究及临床应用，2024.01-2026.12