研究概述：使用多种转基因小鼠，结合动物行为学、分子细胞生物学、神经纤维束路示踪、光遗传学、在体钙成像、电生理等技术，围绕以下方向展开研究：1. 学习记忆、社交活动等的分子及神经环路机制研究；2.抑郁症、精神分裂症等情感障碍性疾病的发病机制及干预研究；3.AD等神经退行性疾病的发病机制及干预研究。
发表论文：
1. Yu H, Li X, Zhang Q, Geng L, Su B, Wang Y*. miR-143-3p modulates depressive-like behaviors via Lasp1 in the mouse ventral hippocampus. Commun Biol. 2024 Aug 5;7(1):944.
2. Zhuang Q, Zhang R, Li X, Ma D, Wang Y*. Identification of the shared molecular mechanisms between major depressive disorder and COVID-19 from postmortem brain transcriptome analysis. J Affect Disord. 2024 Feb 1;346:273-284.
3. Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y*, Li Q, Shao ZH, Yang F, Sun JP. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell. 2023 Nov 22;186(24):5347-5362.e24.
4. Dong B, Wang J, Wang M, Chen Q, Kong X, Chang J, Li X, Yue T, Wang Y*. An FRET-based and ER-targeting fluorescent probe for tracking superoxide anion (O2•-) in the hippocampus of the depressive mouse. Talanta. 2024 Feb 1;268(Pt 1):125272.
5. Zhuang Q, Wang J, Li X, Zhang X, Wang Y*. Key Risk Genes Identified From the Postmortem Brain of Patients With Major Depressive Disorder and Their Potential Clinical Applications. Int J Neuropsychopharmacol. 2023 Jun 23;26(6):396-411.
6. Li X, Yuan RR, Wang Q, Chai S, Zhang Z, Wang Y*, Huang SH. Brain-derived neurotrophic factor regulates LYN kinase-mediated myosin light chain kinase activation to modulate nonmuscle myosin II activity in hippocampal neurons. J Biol Chem. 2022 Jun;298(6):102054.
7. Yaru Sun, Xiaochan Tang, Xiaobing Li, Xiuqi Kong, Minggang Tian, Yue Wang*, Baoli Dong*. PET-ESIPT-based fluorescent probes for revealing the fluctuation of peroxynitrite (ONOO-) in living cells, zebrafishes and brain tissues. Sensors and Actuators B: Chemical. 2022; 353:131121.
8. Xu XF, Jing X, Ma HX, Yuan RR, Dong Q, Dong JL, Han XF, Chen ZY, Li XZ, Wang Y*. miR-181a Participates in Contextual Fear Memory Formation Via Activating mTOR Signaling Pathway. Cereb Cortex. 2018 Sep 1;28(9):3309-3321.
9. Chen XR, Sun SC, Teng SW, Li L, Bie YF, Yu H, Li DL, Chen ZY, Wang Y*. Uhrf2 deletion impairs the formation of hippocampus-dependent memory by changing the structure of the dentate gyrus. Brain Struct Funct. 2018 Mar;223(2):609-618.
10. Jing X, Sui WH, Wang S, Xu XF, Yuan RR, Chen XR, Ma HX, Zhu YX, Sun JK, Yi F, Chen ZY, Wang Y*. HDAC7 Ubiquitination by the E3 Ligase CBX4 Is Involved in Contextual Fear Conditioning Memory Formation. J Neurosci. 2017 Apr 5;37(14):3848-3863.
