研究概述：多糖类药物的研究、开发及抗AD活性研究；小分子荧光药物的设计和筛选及在脑相关疾病防治方面的应用。

发表论文：

1.Tian J, Peng Q, Shen Y, Liu X, Li D, Li J, Guo S, Meng C^#, Xiao Y^#. Chondroitin sulphate modified MoS2 nanoenzyme with multifunctional activities for treatment of Alzheimer's disease. Int J Biol Macromol. 2024 May;266(Pt 2):131425. 

2.Gao Y, Zhang J, Li J, Song S, Zhang S, Liu Q, Wang X, Zhao J, Xia C, Xiao Y^#, Liu T^#. Establishment of environment-sensitive probes targeting BRD3/BRD4 for imaging and therapy of tumor. Eur J Med Chem. 2023 Sep 5;257:115478.

3.Feng Y, Li X, Ji D, Tian J, Peng Q, Shen Y^#, Xiao Y^#. Functionalised penetrating peptide-chondroitin sulphate‑gold nanoparticles: Synthesis, characterization, and applications as an anti-Alzheimer's disease drug. Int J Biol Macromol. 2023 Mar 1;230:123125.

4.Gao D, Li P, Gao F, Feng Y, Li X, Li D, Li Y, Xiao Y^#. Preparation and Multitarget Anti-AD Activity Study of Chondroitin Sulfate Lithium in AD Mice Induced by Combination of D-Gal/AlCl3. Oxid Med Cell Longev. 2022 Nov 12;2022:9466166. 

5.Meng X, Lu Y, Gao Y, Cheng S, Tian F, Xiao Y^#, Li F. Chitosan/alginate/hyaluronic acid polyelectrolyte composite sponges crosslinked with genipin for wound dressing application. Int J Biol Macromol. 2021 Jul 1;182:512-523.

6.Ji D, Wu X, Li D, Liu P, Zhang S, Gao D, Gao F, Zhang M, Xiao Y^#. Protective effects of chondroitin sulphate nano-selenium on a mouse model of Alzheimer's disease. Int J Biol Macromol. 2020 Jul 1;154:233-245.

7.Gao F, Zhao J, Liu P, Ji D, Zhang L, Zhang M, Li Y, Xiao Y^#. Preparation and in vitro evaluation of multi-target-directed selenium-chondroitin sulfate nanoparticles in protecting against the Alzheimer's disease. Int J Biol Macromol. 2020 Jan 1;142:265-276.

8.Liu P, Chen N, Yan L, Gao F, Ji D, Zhang S, Zhang L, Li Y, Xiao Y^#. Preparation, characterisation and in vitro and in vivo evaluation of CD44-targeted chondroitin sulphate-conjugated doxorubicin PLGA nanoparticles. Carbohydr Polym. 2019 Jun 1;213:17-26. 

9.Xiao Y, Li P, Cheng Y, Zhang Q, Wang F. Effect of α-linolenic acid-modified low molecular weight chondroitin sulfate on atherosclerosis in apoE-deficient mice. Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2589-2597.

10.Xiao Y, Li P, Cheng Y, Zhang X, Sheng J, Wang D, Li J, Zhang Q, Zhong C, Cao R, Wang F. Enhancing the intestinal absorption of low molecular weight chondroitin sulfate by conjugation with α-linolenic acid and the transport mechanism of the conjugates. Int J Pharm. 2014 Apr 25;465(1-2):143-58.