研究概述：研究方向是神经系统疾病致病基因的发现和机制研究，主持并完成国家自然科学基金面上项目一个，主持并完成省级自然科学基金一项。
发表论文：
1. Li PP, Zhou YY, Gao L, Lv JN, Xu SS, Zhao YW, Xu D, Huang R, Zhang X, Li P, Fu X#, He Z#. The de novo missense mutation F224S in GABRB2, identified in epileptic encephalopathy and developmental delay, impairs GABAAR function. Neuroscience. 2024 Aug 16;553:172-184.
2. Wang Q, Shi X, Li PP, Gao L, Zhou Y, Li L, Ye H, Fu X#, Li P#. microRNA profilings identify plasma biomarkers and targets associated with pediatric epilepsy patients. Pediatr Res. 2024 Mar;95(4):996-1008.
3. Lu Deng, Hong Jiang, Jingjing Lin, Di Xu, Ailin Qi, Qing Guo, Ping-Ping Li, Xinshi Wang, Judy S Liu, Xiaoqin Fu#, Peijun Li#, Clock knockout in inhibitory neurons reduces predisposition to epilepsy and influences anxiety-like behaviors in mice. Neurobiology of Disease. 2024 Feb 28;193:106457.
4. Fu X*, Rao L, Li P, Liu X, Wang Q, Son AI, Gennerich A, Liu JS. Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking. Elife. 2022 Dec 7;11:e82218.
5. Li P, Li L, Yu B, Wang X, Wang Q, Lin J, Zheng Y, Zhu J, He M, Xia Z, Tu M, Liu JS, Lin Z, Fu X#. Doublecortin facilitates the elongation of the somatic Golgi apparatus into proximal dendrites. Mol Biol Cell. 2021 Mar 1;32(5):422-434.
6. Li P*, Fu X*, Smith NA, Ziobro J, Curiel J, Tenga MJ, Martin B, Freedman S, Cea-Del Rio CA, Oboti L, Tsuchida TN, Oluigbo C, Yaun A, Magge SN, O'Neill B, Kao A, Zelleke TG, Depositario-Cabacar DT, Ghimbovschi S, Knoblach S, Ho CY, Corbin JG, Goodkin HP, Vicini S, Huntsman MM, Gaillard WD, Valdez G, Liu JS. Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy. Neuron. 2017 Oct 11;96(2):387-401.e6.
7. Fu X, Brown KJ, Yap CC, Winckler B, Jaiswal JK, Liu JS. Doublecortin (Dcx) family proteins regulate filamentous actin structure in developing neurons. J Neurosci. 2013 Jan 9;33(2):709-21.
8. Fu X, Zang K, Zhou Z, Reichardt LF, Xu B. Retrograde neurotrophic signaling requires a protein interacting with receptor tyrosine kinases via C2H2 zinc fingers. Mol Biol Cell. 2010 Jan 1;21(1):36-49.
9. Fu X, Ravindranath L, Tran N, Petrovics G, Srivastava S. Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1. DNA Cell Biol. 2006 Mar;25(3):135-41.
10. Fu X, Porter TE. Glucocorticoid induction of lactotrophs and prolactin gene expression in chicken embryonic pituitary cells: a delayed response relative to stimulated growth hormone production. Endocrinology. 2004 Mar;145(3):1322-30.
