研究概述：研究方向聚焦于脑认知障碍及精神疾病的发病机制与干预策略，以脑类淋巴–脑膜淋巴管为切入点，重点解析其在阿尔茨海默病发生发展中的核心作用，并进一步拓展至抑郁症、焦虑症等精神疾病的共病机制研究，旨在阐明脑淋巴系统功能障碍在认知与情绪障碍中的共性规律，为神经精神疾病的发病机制理解与干预策略开发提供新思路。

招生专业/方向： 神经生物学、分子生物学、精神医学、生物信息学

发表论文：

1.Zhan Zhang^#, Shaojian Li^#, Liang Xu^#, Songhua Xiao^#, Yi Li^#, Jialin Huang, Jingxuan Huang, You Zuo, Wenjie Wen, Qingyuan Dai, Chuan Xiao, Xinkai Zhang, Jiongxue Chen, Fuyin Deng, Jinbiao Li, Yongteng Xu, Xia Hu, Zhenhong Deng, Yuan Luo, Xiaoru Xie, Xiaojing Ye^*, Wei-Jye Lin^*, Yamei Tang^*. Amyloid-β-driven glymphatic dysfunction in Alzheimer’s disease model mice is driven by Ca²⁺-mediated increases in astrocytic cholesterol. Nature Neuroscience. 2026; 29:1369–1385.

2.Min Zhang^#, Zhan Zhang^#, Honghong Li, Yuting Xia, Mengdan Xing, Chuan Xiao, Wenbao Cai, Lulu Bu, Yi Li, Tae-Eun Park, Yamei Tang^*, Xiaojing Ye^*, Wei-Jye Lin^*. Blockage of VEGF function by bevacizumab alleviates early-stage cerebrovascular dysfunction and improves cognitive function in a mouse model of Alzheimer's disease. Translational Neurodegeneration. 2024;13(1):1.

3.Zhan Zhang^#, Jingru Jiang^#, Yong He^#, Jinhua Cai, Jiatian Xie, Minyi Wu, Mengdan Xing, Zhenzhen Zhang, Haocai Chang, Pei Yu, Siqi Chen, Yuhua Yang, Zhongshan Shi, Qiang Liu, Haohui Sun, Baixuan He, Junbo Zeng, Jialin Huang, Jiongxue Chen, Honghong Li, Yi Li^*, Wei-Jye Lin^*, Yamei Tang^*. Pregabalin mitigates microglial activation and neuronal injury by inhibiting HMGB1 signaling pathway in radiation-induced brain injury. Journal of Neuroinflammation. 2022;19(1):231.

4.Zhan Zhang, Qi Shen, Xiaolei Wu, Di Zhang, Da Xing^*. Activation of PKA/SIRT1 signaling pathway by photobiomodulation therapy reduces Aβ levels in Alzheimer's disease models. Aging Cell. 2020;19(1):e13054.

5.Jinping Cheng^#, Jingru Jiang^#, Baixuan He^#, Wei-Jye Lin^#, Yi Li^#, Jingjing Duan, Honghong Li, Xiaolong Huang, Jinhua Cai, Jiatian Xie, Zhan Zhang, Yuhua Yang, Yongteng Xu, Xia Hu, Minyi Wu, Xiaohuang Zhuo, Qiang Liu, Zhongshan Shi, Pei Yu, Xiaoming Rong, Xiaojing Ye, Phei Er Saw, Long-Jun Wu, Charles B Simone, Melvin LK Chua, Hai-Qiang Mai, Yamei Tang^*. A phase 2 study of thalidomide for the treatment of radiation-induced blood-brain barrier injury. Science Translational Medicine. 2023;15(684):eabm6543.

6.Zhongshan Shi^#, Pei Yu^#, Wei-Jye Lin^#, Sitai Chen^#, Xia Hu, Siqi Chen, Jinping Cheng, Qiang Liu, Yuhua Yang, Shaojian Li, Zhan Zhang, Jiatian Xie, Jingru Jiang, Baixuan He, Yi Li, Honghong Li, Yongteng Xu, Junbo Zeng, Jialin Huang, Jinghong Mei, Jinhua Cai, Jiongxue Chen, Long-Jun Wu, Ho Ko, Yamei Tang^*. Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8⁺ T lymphocytes. Neuron. 2023;111(5):696-710.e9.

7.Wen Wu^#, Yubai Zhao^#, Xin Cheng^#, Xiaoru Xie, Yixiu Zeng, Quan Tao, Yishuai Yang, Chuan Xiao, Zhan Zhang, Jiahui Pang, Jian Jin, Hongbo He, Yangyang Lin, Boxing Li, Junxian Ma^*, Xiaojing Ye^*, Wei-Jye Lin^*. Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer’s disease. Nature Communications. 2025;16:63.

8.Ying Liu^#, Zhiyuan Ning^#, Qingyuan Dai^#, Xinkai Zhang, Yibin Xiao, Zhan Zhang, Daji Guo, Junhua Chen, Yi Li, Weiqiang Li^*, Songhua Xiao^*, Yamei Tang^*. Intravenously injected hPSC-derived pericytes for Alzheimer disease: Neuroprotection and vascular repair via extracellular vesicles. Molecular Therapy. 2025;33(11), 5681-5703.

9.Qi Shen^#, Haocai Chang^#, Junyu Li, Haoyun Guo, Wenbin Shi, Yihua Yan, Wenwen Ouyang, Zhan Zhang, Xiaolei Wu, Da Xing^*, Sihua Yang^*. Photobiomodulation of immune crosstalk rescues neuroinflammation in Alzheimer’s disease models. Brain. 2026. doi.org/10.1093/brain/awag247.

10.You Zuo^#, Shaojian Li^#, Xiaoqiu Zhu^#, Jingwen Yang^#, Xia Hu, Wenjie Wen, Zhan Zhang, Sitai Chen, Kejia Liu, Zhenhong Deng, Xiaolu Liu, Wei-Jye Lin^*, Zhongshan Shi^*, Yamei Tang^*. Monocyte-derived cells promote transient insult-induced brain injury by enhancing CD8⁺ T cell response. Cell Reports. 2025;44(11), 116528.

科研奖励：

1.广东省生物物理学会青年创新奖，2025年

2.中山大学优秀博士学位论文，2024年

科研项目：

1.国家自然科学基金青年科学基金项目，2025年（主持）；

2.国家资助博士后研究人员计划，2024年（主持）；

3.中国博士后科学基金面上项目，2024年（主持）；

4.广东省博士博士后人才专项支持计划，2024年（主持）；

5.广东省自然科学基金面上项目，2025年（主持）；

6.广东省青年基金项目，2025年（主持）；

7.广东省科学技术协会青年科技人才培育计划，2026年（主持）；

8.激光生命科学教育部重点实验室开放课题基金，2023年（主持）；