研究概述:围绕神经精神药理学领域,开展相关疾病(癫痫、阿尔茨海默病、抑郁等)药物筛选模型和致病风险评价模型的建立、病理机制与药物干预研究。主持国家自然科学基金、科技部“一带一路”创新人才项目等国家级项目5 项,以第一完成人获得“山东省自然科学奖”二等奖、“山东省海洋科技创新奖”二等奖等,任药理学、神经生物学等领域多个国家级学会委员。近5年,以第一作者/通讯作者发表SCI论文48篇(15篇中科院一区,5篇IF大于10),授权发明专利16项。
发表论文:
1. Gao L#, Wang B#, Cui X, Xia L, Li X, Figueredo YN, Li D, Liu K, Wang H*, Jin M*: Neochlorogenic acid ameliorates Alzheimer's disease-like pathology via scavenging oxidative stress and restoring blood-brain barrier function in zebrafish. Progress in neuro-psychopharmacology & biological psychiatry 2025:111334.
2. Liu S, Li X, Jiao S, Zheng Y, Xia L, Figueredo YN, Liu K, Jin M*: Phenyl salicylate induces neurotoxicity and early Alzheimer's disease-like symptoms through ndrg1-regulated myelin damage, increasing bace1 in zebrafish. Science of the total environment 2025, 965:178664.
3. Jin M#, Shi R#, Gao D, Wang B, Li N, Li X, Sik A, Liu K*, Zhang X*: ErbB2pY-1248 as a predictive biomarker for Parkinson's disease based on research with RPPA technology and in vivo verification. CNS neuroscience & therapeutics 2024, 30(2):e14407.
4. Shi R#, Gao D#, Stoika R, Liu K, Sik A*, Jin M*: Potential implications of polyphenolic compounds in neurodegenerative diseases. Critical reviews in food science and nutrition 2024, 64(16):5491-5514.
5. Gao X, Zhang B, Zheng Y, Liu X, Rostyslav P, Finiuk N, Sik A, Stoika R, Liu K, Jin M*: Neuroprotective effect of chlorogenic acid on Parkinson's disease like symptoms through boosting the autophagy in zebrafish. European journal of pharmacology 2023, 956:175950.
6. Ren Q#, Jiang X#, Paudel YN, Gao X, Gao D, Zhang P, Sheng W, Shang X, Liu K, Zhang X*, Jin M*: Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish. Journal of ethnopharmacology 2022, 292:115234.
7. Jin M#, Li N#, Sheng W, Ji X, Liang X*, Kong B, Yin P, Li Y, Zhang X, Liu K*: Toxicity of different zinc oxide nanomaterials and dose-dependent onset and development of Parkinson's disease-like symptoms induced by zinc oxide nanorods. Environment international 2021, 146:106179.
8. Dang J#, Paudel YN#, Yang X#, Ren Q, Zhang S, Ji X, Liu K, Jin M*: Schaftoside suppresses pentylenetetrazol-induced seizures in zebrafish via suppressing apoptosis, modulating inflammation, and oxidative stress. ACS chemical neuroscience 2021, 12(13):2542-2552.
9. Jin M#,*, Zhang B#, Sun Y#, Zhang S, Li X, Sik A, Bai Y*, Zheng X*, Liu K*: Involvement of peroxisome proliferator-activated receptor gamma in anticonvulsant activity of alpha-asaronol against pentylenetetrazole-induced seizures in zebrafish. Neuropharmacology 2020, 162:107760.
10. Zhang B#, Wang L#, Ji X#, Zhang S, Sik A, Liu K, Jin M*: Anti-inflammation associated protective mechanism of berberine and its derivatives on attenuating pentylenetetrazole-induced seizures in zebrafish. Journal of neuroimmune pharmacology 2020, 15(2):309-325.
主持课题:
1.泰山学者青年专家项目(tsqn202312233),2024.01-2026.12,75万,主持;
2.国家高端外国专家引进计划(H20240744),2024.01-2025.12,30万,主持;
3.国家重点研发计划青年科学家项目(2023YFC3505000),2023.11-2026.10,40/300万,任务负责人;
4.国家科学技术部“一带一路”创新人才交流项目,(DL2021023004L),2021.01-2022.12,30万,主持;
5.济南市“新高校20条”高校院所科研带头人工作室(2021GXRC106),2022.01-2024.12,20万,主持;
6.国家自然科学基金青年基金(81802629),2019.01-2021.12,21万,主持。