研究概述：2014年在山东省阳谷县闫楼镇建立了脑老化与痴呆队列，2017年建立了我国首个老年痴呆多模干预研究队列-MIND-China (中国延缓老年痴呆和失能的随机化对照多模干预研究)，系统开展老年痴呆的早期防治策略和干预新方法的研究，取得了系列研究成果。

发表论文：

1.Hou T, Liu K, Fa W, Liu C, Zhu M, Liang X, Ren Y, Xu S, Wang X, Tang S, Wang Y, Cong L, Tan Q, Du Y^*, Qiu C^*. Association of polygenic risk scores with Alzheimer's disease and plasma biomarkers among Chinese older adults: A community-based study. Alzheimers Dement. 2024 Oct;20(10):6669-6681.

2.Zhu M, Tian X, Han X, Ma Y, Fa W, Wang N, Liu R, Dong Y, Ren Y, Liu C, Tian N, Zhang H, Song L, Tang S, Cong L, Wang Y, Hou T^*, Qiu C^*, Du Y; Alzheimer's Disease Neuroimaging Initiative. Synergistic associations of CD33 variants and hypertension with brain and cognitive aging among dementia-free older adults: A population-based study. Alzheimers Dement. 2024 Oct;20(10):7193-7204.

3.Wang J, Han X, Li Y, Fa W, Zhao M, Li C, Mao M, Hou T, Wang Y, Cong L, Song L, Du Y, Qiu C. Strategic Lacunes Associated With Mild Cognitive Impairment in Rural Chinese Older Adults: A Population-Based Study. Stroke. 2024 May;55(5):1288-1298.

4.Liu C, Liu R, Tian N, Fa W, Liu K, Wang N, Zhu M, Liang X, Ma Y, Ren Y, Wang Y, Cong L, Tang S, Vetrano DL, Ngandu T, Kivipelto M, Hou T^*, Du Y^*, Qiu C. Cardiometabolic multimorbidity, peripheral biomarkers, and dementia in rural older adults: The MIND-China study. Alzheimers Dement. 2024 Sep;20(9):6133-6145.

5.Ren Y, Li Y, Tian N, Liu R, Dong Y, Hou T, Liu C, Han X, Han X, Wang L, Vetrano DL, Ngandu T, Marengoni A, Kivipelto M, Wang Y, Cong L^*, Du Y^*, Qiu C^*. Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults: A population-based study. Alzheimers Dement. 2024 Mar;20(3):1550-1561.

6.Dong Y, Li Y, Liu K, Han X, Liu R, Ren Y, Cong L, Zhang Q, Hou T, Song L, Tang S, Shi L, Luo Y, Kalpouzos G, Laukka EJ, Winblad B, Wang Y^*, Du Y^*, Qiu C. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimers Dement. 2023 Feb;19(2):589-601.

7.Cong L, Ren Y, Wang Y, Hou T, Dong Y, Han X, Yin L, Zhang Q, Feng J, Wang L, Tang S, Grande G, Laukka EJ, Du Y^*, Qiu C^*. Mild cognitive impairment among rural-dwelling older adults in China: A community-based study. Alzheimers Dement. 2023 Jan;19(1):56-66.

8.Liang X, Fa W, Wang N, Peng Y, Liu C, Zhu M, Tian N, Wang Y, Han X, Qiu C, Hou T^*, Du Y^*. Exosomal miR-532-5p induced by long-term exercise rescues blood-brain barrier function in 5XFAD mice via downregulation of EPHA4. Aging Cell. 2023 Jan;22(1):e13748.

9.Han X, Wang C, Song L, Wang X, Tang S, Hou T, Liu C, Liang X, Qiu C, Wang Y^*, Du Y^*. KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion. EBioMedicine. 2022 Apr;78:103980. 

10.Song L^#, Tang S^#, Han X, Jiang Z, Dong L, Liu C, Liang X, Dong J, Qiu C, Wang Y^*, Du Y^*. KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a. Nat Commun. 2019 Apr 9;10(1):1639.