研究概述：长期从事神经精神疾病如物质成瘾、睡眠障碍和神经退行性疾病等的分子神经环路机制研究及新型药物研发工作。

发表论文：

1. Zou G^*, Xia J^*, Luo H, Xiao D, Jin J, Miao C, Zuo X, Gao Q, Zhang Z, Xue T, You Y, Zhang Y, Zhang L, Xiong W. Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells. Nat Metab. 2022 Sep;4(9):1138-1149.

2. Jin J, Fu C, Xia J, Luo H, Wang X, Chen S, Mao H, Yuan K, Lu L^#, Xiong W^#, Zou G^#. Cannabidiol ameliorates cognitive decline in 5×FAD mouse model of Alzheimer's disease through potentiating the function of extrasynaptic glycine receptors. Mol Psychiatry. 2024 Oct 12.

3. Zou G^*, Zuo X^*, Chen K, Ge Y, Wang X, Xu G, Wang H, Miao C, Xu Z, Tian S, Wang Z, Zhou Y, Wei W, Huang G, Liu D, Xiong W. Cannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction. Cell Rep. 2020 Mar 24;30(12):4209-4219.e7.

4. Hou Y^*, Zou G^*, Wang X, Guo H, Ma X, Cheng X, Xie Z, Zuo X, Xia J, Mao H, Yuan M, Chen Q, Cao P, Yang Y, Zhang L, Xiong W^#. Coordinated activity of a central pathway drives associative opioid analgesic tolerance. Sci Adv. 2023 Feb 10;9(6):eabo5627.

5. Ye J^*, Zou G^*, Zhu R, Kong C, Miao C, Zhang M, Li J, Xiong W, Wang C. Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission. Nat Commun. 2021 Jan 12;12(1):297.

6. Zhu H^*, Zou G^*, Wang N^*, Zhuang M, Xiong W, Huang G. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2586-2591.

7. Jing Xia^*, Dan Xiao^*, Heyi Luo, Jin Jin, Siyuan Ge, Xianglian Wang, Guichang Zou^#, Wei Xiong^#. Cannabinoid Suppresses Neuropathic Pain by Utilizing Spinal Glycine Receptor-mediated Compensation. J Biol Chem, 2023, 6:104769.

8. Zou G, Chen Q, Chen K, Zuo X, Ge Y, Hou Y, Pan T, Pan H, Liu D, Zhang L, Xiong W. Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABA_A Receptors. iScience. 2019 Sep 27;19:634-646. 

9. Zou G, Xia J, Han Q, Liu D, Xiong W. The synthetic cannabinoid dehydroxylcannabidiol restores the function of a major GABAA receptor isoform in a cell model of hyperekplexia. J Biol Chem. 2020 Jan 3;295(1):138-145.

10. Guo Y^*, Zou G^*, Qi K, Jin J, Yao L, Pan Y, Xiong W. Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice. Mol Brain. 2021 Feb 24;14(1):41. 

主持课题：

1.国家自然科学基金，面上项目，抑制性甘氨酸受体介导大麻二酚调控阿尔茨海默病的神经机制研究，2025-01至2028-12，60万；

2.泰山学者青年专家项目，AS-LncRNA-GLYA1 靶向甘氨酸受体调控癫痫᯿ 积状态的机制及干预研究，2024-01至2026-12，75万；

3.山东省教育厅，山东省高等学校“青 创 团 队计划 ”，2024-01至2026-12，50万；