研究概述：要从事“组织损伤与修复及其相关转录调控机制”研究工作，在疾病稳态平衡的表观遗传学调控领域以转录调控因子为分子靶点深入挖掘其在不同组分细胞中的功能，通过阐明细胞-细胞间对话以及胞外-胞内信号转导机制，探究其在疾病中发挥重要调控作用。研究成果获省科学技术奖（自然科学）一等奖一项，主持国家自然科学基金青年基金项目及省自然科学基金青年基金项目各一项。近五年在Gut、Adv Sci、Hepatology、Acta Pharm Sin B、Redox Biol、EMBO Mol Med、JHEP Rep、Cell Death Dis等国际期刊以第一作者或通讯作者身份发表SCI研究论文二十余篇，其中一区12篇，累计影响因子＞170。目前担任江苏省病理生理学会青年工作委员会副主任委员、Life Sciences杂志特刊编辑。
发表论文：
1. Kong M, Zhou J, Kang A, Kuai Y, Xu H, Li M, Miao X, Guo Y, Fan Z, Xu Y, Li Z#. Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis. Gut. 2024 Apr 5;73(5):810-824.
2. Zhou J, Sun X, Chen X, Liu H, Miao X, Guo Y, Fan Z, Li J, Xu Y, Li Z#. Phosphatidic acid-enabled MKL1 contributes to liver regeneration: Translational implication in liver failure. Acta Pharm Sin B. 2024 Jan;14(1):256-272.
3. Fan Z, Sun X, Chen X, Liu H, Miao X, Guo Y, Xu Y, Li J, Zou X, Li Z#. C-C motif chemokine CCL11 is a novel regulator and a potential therapeutic target in non-alcoholic fatty liver disease. JHEP Rep. 2023 May 26;5(9):100805.
4. Kong M, Dong W, Kang A, Kuai Y, Xu T, Fan Z, Shi L, Sun D, Lu Y, Li Z#, Xu Y. Regulatory role and translational potential of CCL11 in liver fibrosis. Hepatology. 2023 Jul 1;78(1):120-135.
5. Sun X, Wang S, Miao X, Zeng S, Guo Y, Zhou A, Chen Y, Chen Y, Lv F, Fan Z, Wang Y, Xu Y, Li Z. TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response. Cell Death Dis. 2023 Jun 24;14(6):372.
6. Guo Y, Miao X, Sun X, Li L, Zhou A, Zhu X, Xu Y, Wang Q, Li Z, Fan Z. Zinc finger transcription factor Egf1 promotes non-alcoholic fatty liver disease. JHEP Rep. 2023 Mar 9;5(6):100724.
7. Li N, Liu H, Xue Y, Xu Z, Miao X, Guo Y, Li Z#, Fan Z#, Xu Y#. Targetable Brg1-CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking. EMBO Mol Med. 2023 Mar 8;15(3):e16592.
8. Dong W, Kong M, Liu H, Xue Y, Li Z#, Wang Y#, Xu Y#. Myocardin-related transcription factor A drives ROS-fueled expansion of hepatic stellate cells by regulating p38-MAPK signalling. Clin Transl Med. 2022 Feb;12(2):e688.
9. Kong M, Dong W, Zhu Y, Fan Z, Miao X, Guo Y, Li C, Duan Y, Lu Y#, Li Z#, Xu Y#. Redox-sensitive activation of CCL7 by BRG1 in hepatocytes during liver injury. Redox Biol. 2021 Oct;46:102079.
10. Li Z*, Zhao Q*, Lu Y*, Zhang Y, Li L, Li M, Chen X, Sun D, Duan Y, Xu Y. DDIT4 S-Nitrosylation Aids p38-MAPK Signaling Complex Assembly to Promote Hepatic Reactive Oxygen Species Production. Adv Sci (Weinh). 2021 Sep;8(18):e2101957. doi: 10.1002/advs.202101957. Epub 2021 Jul 26. Erratum in: Adv Sci (Weinh). 2022 May;9(13):e2201652.
主持课题：
泰山学者青年专家项目，组蛋白甲基化转移酶SETD1A调控衰老相关肝脏再生机制研究，2025.01-2027.12，60万；
