研究概述：主要研究方向为阿尔茨海默病与睡眠障碍的临床和基础研究。依已建立的MIND-China队列为研究基础，探索睡眠片段化、日间嗜睡、睡眠节律、OSA等睡眠障碍在AD进展过程中的作用；侧重于睡眠与AD的人群干预、临床应用和多学科间融合，开发并建立老年人的睡眠评估及AD早期干预方案，为延缓认知功能损害和痴呆的临床发病奠定坚实的基础。

发表论文：

1.Shi Tang, Rui Liu, Juan Ren, Lin Song, Lingling Dong, Yu Qin, Mingqing Zhao, Yongxiang Wang, Yi Dong, Tong Zhao, Cuicui Liu, Tingting Hou, Lin Cong, Shireen Sindi, Bengt Winblad, Yifeng Du^*, Chengxuan Qiu^*. Association of Objective Sleep Duration with Cognition and Brain Aging Biomarkers in Older Adults. Brain Comun, 2024 Apr 26;6(3):fcae144.

2.Yaran Li, Zian Yan, Na Shao, Shi Tang^*, Xiao Zhang, Xiao min Liu, Jiyou Tang. Dual orexin receptor antagonist ameliorates sleep deprivation-induced learning and memory impairment in APP/PS1 mice. Sleep Med, 2024 Sep;121:303-314.

3.Juan Ren, Rui Liu, Tong Zhao, Jie Lu, Cuicui Liu, Tingting Hou, Yongxiang Wang, Lin Cong, Yifeng Du^*, Shi Tang^*, Chengxuan Qiu. Prevalence and associated factors of excessive daytime sleepiness in rural older adults: a population-based study. Sleep Breath. 2024 Jun;28(3):1459-1464.

4.Tong Zhao^#, Rui Liu^#, Qi Han, Xiaolei Han, Juan Ren, Ming Mao, Jie Lu, Lin Cong, Yongxiang Wang, Shi Tang^*, Yifeng Du^*, Chengxuan Qiu. Associations of 24-hour movement behaviors with depressive symptoms in rural-dwelling older adults: a compositional data analysis. Aging Clin Exp Res.2024 Aug 9;36(1):165.

5.Rui Liu, Yifei Ren, Tingting Hou, Xiaoyan Liang, Yi Dong, Yongxiang Wang, Lin Cong, Xiang Wang, Yu Qin, Juan Ren, Shireen Sindi, Shi Tang^*, Yifeng Du^*, Chengxuan Qiu. Associations of sleep timing and time in bed with dementia and cognitive decline among Chinese older adults: A cohort study. J Am Geriatr Soc. 2022 Nov;70(11):3138-3151.

6.Yu Qin^#, Rui Liu^#, Yongxiang Wang, Jiyou Tang, Lin Cong, Juan Ren, Shi Tang^*, Yifeng Du^*. Self-Reported Sleep Characteristics Associated with Cardiovascular Disease Among Older Adults Living in Rural Eastern China: A Population-Based Study. Clin Interv Aging. 2022 May 18;17:811-824.

7.Peng Wang, Lin Song, Kaili Wang, Xiaolei Han, Lin Cong 1, Yongxiang Wang, Lei Zhang, Zhongrui Yan, Shi Tang^*, Yifeng Du^*. Prevalence and associated factors of poor sleep quality among Chinese older adults living in a rural area: a population-based study. Aging Clin Exp Res. 2020 Jan;32(1):125-131.

8.Lin Song^#, Shi Tang^#, Xiaolei Han, Ziying Jiang, Lingling Dong, Cuicui Liu, Xiaoyan Liang, Jixin Dong, Chengxuan Qiu, Yongxiang Wang^*, Yifeng Du^*. KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a. Nat Commun. 2019 Apr 9;10(1):1639.