研究概述：主要研究方向为糖代谢与阿尔茨海默病的临床和基础研究，以人群队列和动物模型为抓手，揭示糖代谢失衡与AD发病关联，阐明糖代谢紊乱及其调控AD病理的分子机制，寻找AD早期诊断和干预靶点。
发表论文：
1.Tian N, Song L, Hou T, Fa W, Dong Y, Liu R, Ren Y, Liu C, Zhu M, Zhang H, Wang Y, Cong L, Du Y, Qiu C. Association of Triglyceride-Glucose Index With Cognitive Function and Brain Atrophy: A Population-Based Study. Am J Geriatr Psychiatry. 2024 Feb;32(2):151-162.
2.Tian N, Fa W, Dong Y, Liu R, Liu C, Liu K, Mao M, Zhu M, Liang X, Wang N, Ma Y, Ngandu T, Launer LJ, Wang Y, Hou T, Du Y, Qiu C. Triglyceride-glucose index, Alzheimer's disease plasma biomarkers, and dementia in older adults: The MIND-China study. Alzheimers Dement (Amst). 2023 Apr 23;15(2):e12426.
3.Tian N, Hu L, Lu Y, Tong L, Feng M, Liu Q, Li Y, Zhu Y, Wu L, Ji Y, Zhang P, Xu T, Tong X. TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis. Cell Death Dis. 2021 Sep 17;12(10):853.
4.Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L, Tong X. Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis. Diabetes. 2020 Jul;69(7):1355-1367.
5.Lu Y#, Tian N#, Hu L#, Meng J, Feng M, Zhu Y, Zhang P, Li M, Liu Q, Tong L, Tong X, Li Y, Wu L. ERα down-regulates carbohydrate responsive element binding protein and decreases aerobic glycolysis in liver cancer cells. J Cell Mol Med. 2021 Apr;25(7):3427-3436.
6.Li Y#, Yang D#, Tian N#, Zhang P, Zhu Y, Meng J, Feng M, Lu Y, Liu Q, Tong L, Hu L, Zhang L, Yang JY, Wu L, Tong X. The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation. J Biol Chem. 2019 Oct 4;294(40):14745-14756.
7.Liu C, Liu R, Tian N, Fa W, Liu K, Wang N, Zhu M, Liang X, Ma Y, Ren Y, Wang Y, Cong L, Tang S, Vetrano DL, Ngandu T, Kivipelto M, Hou T, Du Y, Qiu C. Cardiometabolic multimorbidity, peripheral biomarkers, and dementia in rural older adults: The MIND-China study. Alzheimers Dement. 2024 Sep;20(9):6133-6145.
8.Ren Y, Li Y, Tian N, Liu R, Dong Y, Hou T, Liu C, Han X, Han X, Wang L, Vetrano DL, Ngandu T, Marengoni A, Kivipelto M, Wang Y, Cong L, Du Y, Qiu C. Multimorbidity, cognitive phenotypes, and Alzheimer's disease plasma biomarkers in older adults: A population-based study. Alzheimers Dement. 2024 Mar;20(3):1550-1561.
9.Liu Q, Zhu F, Liu X, Lu Y, Yao K, Tian N, Tong L, Figge DA, Wang X, Han Y, Li Y, Zhu Y, Hu L, Ji Y, Xu N, Li D, Gu X, Liang R, Gan G, Wu L, Zhang P, Xu T, Hu H, Hu Z, Xu H, Ye D, Yang H, Li B, Tong X. Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics. Nat Metab. 2022 May;4(5):559-574.
