研究概述：一直致力于组织工程与再生医学技术用于损伤修复与功能重建相关研究，在生物医用材料研发、体外组织构建及其形态精确调控、生物反应器研发、干细胞组织再生核心技术、大动物模型缺损修复以及组织再生技术临床应用等方面提出了新思路和解决方案。 研究成果发表于 Science advances、Advanced Functional Materials、Bioactive Materials、Composites Part B-Engineering等本领域权威期刊。基于软骨再生技术临床转化研究成果，作为主要完成人申获山东省科技进步奖一等奖，作为负责人主持组织修复与功能重建研究方向密切相关的国家重点研发计划子课题 3 项、国家自然科学基金面上项目、青年基金、泰山学者青年专家及中国博士后科学基金面上项目，累计科研经费646万元。

发表论文：

1.Zheng Ci^#, Yingying Huo^#, Bin Tang^#, Genke Li, Zenghui Jia, Peiling Zhang, Pengli  Wang, Jie Zhu, Xiao Song, Huitang Xia^*, Liang Duan^*, Guangdong Zhou^*. Microstructure modified decalcified bone matrix scaffolds and bone marrow stem cell– chondrocyte co-cultures promote stable cartilage regeneration. Composites Part B 291 (2025) 111976.

2.Wenbao He^#, Chunlin Li^#, Zhendong Li, Jing Wu, Junjun Li, Haichao Zhou^*, Yunfeng Yang^*, Yong Xu^*, Huitang Xia^*. Integrating Coaxial Electrospinning and 3D Printing Technologies for the Development of Biphasic Porous Scaffolds Enabling Spatiotemporal Control in Tumor Ablation and Osteochondral Regeneration. Bioactive Materials 34 (2024) 338–353.

3.Zehan Shang^#, Zihao Liu^#, Min Han^#, Hao Fan, Dongxiao Lu, Yuming Li, Zijian Zhou, Xiaofeng Wang, Bingcheng Wang, Zhihai Wang, Baogeng Huai, Xianyong Yin, Youqiang Cui, Huitang Xia^*, Shan Wang^*, Tao Xin^*. Individualized bio-scaffold encapsulating siPTEN-loaded exosomes for promoting neuronal regeneration in spinal cord injury. Composites Part B. 270 (2024) 111146.

4.Erji Gao^#, Yao Wang^#, Pengli Wang^#, Qianyi Wang^#, Daiying Song, Huangfang Xu, Gening Jiang, Yong Xu^*, Huitang Xia^*, Ru Chen^*,Liang Duan^*. C-shaped cartilage development using Wharton’s jelly-derived hydrogels to assemble a highly biomimetic neotrachea for use in circumferential tracheal reconstruction. Adv. Funct. Mater. 2023, 2212830. DOI: 10.1002/adfm.202212830.

5.Wei Gao^#, Kai Chen^#, Wenbao He^#, Shitong Zhao, Dongming Cui, Chunsheng Tao, Yong Xu^*, Xiufeng Xiao^*, Qian Feng^*, Huitang Xia^*. Synergistic Chondrogenesis Promotion and Arthroscopic Articular Cartilage Restoration via Injectable Dual-Drug-Loaded Sulfated Hyaluronic Acid Hydrogel for Stem Cell Therapy. Composites Part B. 263 (2023) 110857.

6.Erji Gao^# , Gao Li^#, Runfeng Cao^# , Huitang Xia ^#* , Yong Xu , Gening Jiang, Kaiyan Xiao, Jie Chen^* , Ru Chen^* , Liang Duan^*, Bionic tracheal tissue regeneration using a ring-shaped scaffold comprised of decellularized cartilaginous matrix and silk fibroin. Composites Part B 229 (2022) 109470.

7.Cao R^#, Xu Y^#, Xu Y, Brand DD, Zhou G, Xiao K^*, Xia H^*, Czernuszka JT*. Development of Tri-layered Biomimetic Atelocollagen Scaffolds with Interfaces for Osteochondral Tissue Engineering. Adv Healthc Mater. 2022 Feb 8:e2101643.

8.Yujie Hua^#, Huitang Xia^#, Litao Jia^#, Jinzhong Zhao, Dandan Zhao, Xiaoyu Yan , Yiqing Zhang, Shengjian Tang, Guangdong Zhou*, Linyong Zhu, Qiuning Lin^*. Ultrafast, tough, and adhesive hydrogel based on hybrid photocrosslinking for articular cartilage repair in water-filled arthroscopy. Sci. Adv. 2021; 7 : eabg0628.

9.Tonghe Zhu, Hongbing Gu, Hongmei Zhang ,Hongsheng Wang, Huitang Xia^*, Xiumei Mo^*, Jinglei Wu*. Covalent grafting of PEG and heparin improves biological performance of electrospun vascular grafts for carotid artery replacement. Acta Biomater. 2021 Jan 1;119:211-224.

10.Wei Gao^#, Tan Cheng^#, Zhengya Tang^#, Wenqiang Zhang, Min Han, Guangdong Zhou, Chunsheng Tao^*, Ning Xu^*, Huitang Xia^*, Weijie Sun^*. Enhancing Cartilage Regeneration and Repair through Bioactive and Biomechanical Modification of 3D Acellular Dermal Matrix. Regenerative Biomaterials. DOI: 10.1093/rb/rbae010.