研究概述：长期致力于在中枢神经系统损伤修复中的临床及基础研究，利用生物3D打印、类器官构建、影像学分析及多组学测序技术，结合干细胞外泌体、发光诊疗探针及纳米酶材料，研究多类型工程化修饰的干细胞外泌体在继发性神经元损伤修复中的神经保护作用及分子机制，构建可实现临床转化的药物及生物制剂缓释系统。

发表论文：

1.Xingyu Gui, Ping Song, Boqing Zhang, Haoyuan Lei, Lina Wu, Jiayi Sun, Rong Tang, Hui Zhang, Yuxiang Qin, Zixuan Su, Jianxun Sun, Zhihe Zhao, Min Han^*, Wei Wei^*, Yujiang Fan, Changchun Zhou^*, Natural loofah sponge inspired 3D printed bionic scaffolds promote personalized bone defect regeneration, Composites Part B: Engineering, Volume 288, 2025, 111920.

2.Zehan Shang^#, Zihao Liu^#, Min Han^#, Hao Fan, Dongxiao Lu, Zijian Zhou, Zhihai Wang, Yuming Li, Xiaofeng Wang, Bingcheng Wang, Baogeng Huai, Youqiang Cui, Huitang Xia^*, Shan Wang*, Tao Xin^*. Individualized bio-scaffold encapsulating siPTEN-loaded exosomes for promoting neuronal regeneration in spinal cord injury, Composites Part B: Engineering, Volume 270, 2024, 111146.

3.Qiong Zhang, Tiangui Liu, Yuming Li, Yang Fan, Hao Shang, Huayang Zhao, Haohan Sun, Zaiyang Yu, Min Han^*, Chunxiao Wan^*. Gelatin methacryloyl microneedle loaded with 3D-MSC-Exosomes for the protection of ischemia-reperfusion. Int J Biol Macromol. 2024 Aug;275(Pt 1):133336.

4.Min Han^#, Zihao Zhang^#, Zihao Liu, Yu Liu, Huayang Zhao, Bingcheng Wang, Canwei Zhang, Hao Shang, Yuming Li, Shan Wang^*, Tao Xin^*. Three-dimensional-cultured MSC-derived exosome with hydrogel for cerebral ischemia repair. Biomaterials Advances. 2023 Mar 22; 149:213396.

5.Min Han^#, Hongru Yang^#, Xiangdong Lu, Yuming Li, Zihao Liu, Feng Li, Zehan Shang, Xiaofeng Wang, Xuze Li, Junliang Li, Hong Liu^*, Tao Xin^*. Three-Dimensional-Cultured MSC-Derived Exosome-Hydrogel Hybrid Microneedle Array Patch for Spinal Cord Repair. Nano Letters. 2022. 22(15):6391-6401.

6.Hongru Yang^#, Min Han^#, Jian Li, Hongfei Ke, Ying Kong, Wenhan Wang, Liang Wang, Wenjun Ma, Jichuan Qiu^*, Xiwei Wang^*, Tao Xin^*, Hong Liu^*. Delivery of miRNAs through Metal-Organic Framework Nanoparticles for Assisting Neural Stem Cell Therapy for Ischemic Stroke. ACS NANO. 2022. 16(9):14503-14516.

7.Min Han^#, Dexiang Liu^#, Jie Qiu, Hongtao Yuan, Quan Hu, Hao Xue, Tingting Li, WeiWei Ma, Qiong Zhang, Gang Li^*, Zhen Wang^*. Evaluation of H₂S-producing enzymes in cerebrospinal fluid and its relationship with interleukin-6 and neurologic deficits in subarachnoid hemorrhage. Biomedicine & Pharmacotherapy. 2020 Mar; 123:109722.

8.Min Han, Ying Cao, Hao Xue, Xili Chu, Tingting Li, Danqing Xin, Lin Yuan, Hongfei Ke, Gang Li^*, Zhen Wang*. Neuroprotective effect of mesenchymal stem cell-derived extracellular vesicles against cerebral ischemia-reperfusion-induced neural functional injury: A pivotal role for AMPK and JAK2/STAT3/NF-κB signaling pathway modulation. Drug design, development and therapy. 2020 Jul 20; 14:2865-2876.

9.Min Han, Ying Cao, Xiaofan Guo, Xili Chu, Tingting Li, Hao Xue, Danqing Xin, Lin Yuan, Hongfei Ke, Gang Li^*, Zhen Wang^*. Mesenchymal stem cell-derived extracellular vesicles promote microglial M2 polarization after subarachnoid hemorrhage in rats and involve the AMPK/NF-κB signaling pathway. Biomedicine & Pharmacotherapy. 2021 Jan; 133:111048.