研究概述：1. 基于老年和大学生人群队列阐明睡眠和认知障碍疾病的流行病学特征、危险因素和干预策略；2. 从基因-环境-脑老化交互作用的角度阐明睡眠和认知障碍疾病的发病机制和神经环路；3. 抗神经系统疾病新型小分子药物设计、筛选、验证及新药先导化合物研究。

发表论文：

1. Liu X^*, Xiong W^*, Ye M, Lu T, Yuan K, Chang S, Han Y, Wang Y^#, Lu L^#, Bao Y^#. Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets. Signal Transduct Target Ther. 2023 Dec 6;8(1):441.

2. Wang Y, Han Q, Han X, Dong Y, Mao M, Wang C, Wang X, Tang S, Liu C, Li Y, Hou T, Cong L, Du Y^#, Qiu C^#. Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study. Immun Ageing. 2023 Jul 25;20(1):36. 

3. Han Q^*, Han X^*, Wang X, Wang C, Mao M, Tang S, Cong L, Hou T, Liu C, Wang Y^#, Du Y^#, Qiu C. Association of Accelerometer-Measured Sedentary Behavior Patterns With Nonalcoholic Fatty Liver Disease Among Older Adults: The MIND-China Study. Am J Gastroenterol. 2023 Mar 1;118(3):569-573. 

4. Dong Y, Li Y, Liu K, Han X, Liu R, Ren Y, Cong L, Zhang Q, Hou T, Song L, Tang S, Shi L, Luo Y, Kalpouzos G, Laukka EJ, Winblad B, Wang Y^#, Du Y^#, Qiu C. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimers Dement. 2023 Feb;19(2):589-601. 

5. Han X, Wang C, Song L, Wang X, Tang S, Hou T, Liu C, Liang X, Qiu C, Wang Y^#, Du Y^#. KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion. EBioMedicine. 2022 Apr;78:103980. 

6. Song L^*, Tang S^*, Han X, Jiang Z, Dong L, Liu C, Liang X, Dong J, Qiu C, Wang Y^#, Du Y^#. KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a. Nat Commun. 2019 Apr 9;10(1):1639. 

主持课题：

1. Alzheimer's Association（阿尔茨海默病协会），Clinician Scientist Fellowship to Promote Diversity，AACSFD-22-922844，Plasma biomarkers in the continuum from normal cognition through MCI to AD，2022-03至2025-03，105万元，在研，主持；

2. 国家自然科学基金委员会，面上项目，82171175，神经源性外泌体介导KIBRA基因单体型在Aβ代谢的功能和机制研究，2022-01-01至2025-12-31，55万元，在研，主持；

3. 山东省自然科学基金委员会，面上项目，ZR2021MH005，记忆相关基因KIBRA通过神经源性外泌体介导Aβ代谢的研究，2022-01至2024-12，10万元，在研，主持。