研究概述：采用分子生物学、靶向代谢组学、多模态影像和神经电生理等技术手段，对神经系统肿瘤、神经退行性疾病及中枢神经损伤修复进行机制解析与干预研究

发表论文：

1.Yang H, Han M, Li J, Ke H, Kong Y, Wang W, Wang L, Ma W, Qiu J, Wang X^#, Xin T^#, Liu H^#. Delivery of miRNAs through Metal-Organic Framework Nanoparticles for Assisting Neural Stem Cell Therapy for Ischemic Stroke. ACS Nano. 2022 Sep 27;16(9):14503-14516.

2.Wang L, Zhao H, Han M, Yang H, Lei M, Wang W, Li K, Li Y, Sang Y^#, Xin T^#, Liu H^#, Qiu J^#. Electromagnetic Cellularized Patch with Wirelessly Electrical Stimulation for Promoting Neuronal Differentiation and Spinal Cord Injury Repair. Adv Sci (Weinh). 2024 Aug;11(30):e2307527. 

3.Qiao N^*, Gao W^*, Deng X^*, Xin T^*, Zhang G^*, Wu N^*, Wang P, Bi Y, Cong Z, Zhou Z, Li J, Sun S, Li M, Tang W, Yan X, Wang W, Qiu W, Yao S, Ye Z, Ma Z, Zhou X, Cao X, Shen M, Shou X, Zhang Z, Wu Z, Chu L, Qiu Y, Ma H, Wu A, Ma C, Lou M, Jiang C, Wang Y, Zhao Y. Combined simultaneous transsphenoidal and transcranial regimen improves surgical outcomes in complex giant pituitary adenomas: a longitudinal retrospective cohort study. Int J Surg. 2024 Jul 1;110(7):4043-4052.

4.Zehan Shang^*, Zihao Liu^*, Min Han*, Hao Fan, Dongxiao Lu, Zijian Zhou, Zhihai Wang, Yuming Li, Xiaofeng Wang, Bingcheng Wang, Baogeng Huai, Youqiang Cui,Huitang Xia, Shan Wang^#, Tao Xin^#.Individualized bio-scaffold encapsulating siPTEN-loaded exosomes for promoting neuronal regeneration in spinal cord injury. Composites Part B. 2024, 270: 111146.

5.Ji X, Liu Z, Gao J, Bing X, He D, Liu W, Wang Y, Wei Y, Yin X, Zhang F, Han M, Lu X, Wang Z, Liu Q^#, Xin T^#. N6-Methyladenosine-modified lncRNA LINREP promotes Glioblastoma progression by recruiting the PTBP1/HuR complex. Cell Death Differ. 2023 Jan;30(1):54-68. 

6.He D^*, Xin T^*, Pang B, Sun J, Liu ZH, Qin Z, Ji XS, Yang F, Wei YB, Wang ZX, Gao JJ, Pang Q, Liu Q. A novel lncRNA MDHDH suppresses glioblastoma multiforme by acting as a scaffold for MDH2 and PSMA1 to regulate NAD+ metabolism and autophagy. J Exp Clin Cancer Res. 2022 Dec 17;41(1):349.

7.Li J, Liu Q, Liu Z, Xia Q, Zhang Z, Zhang R, Gao T, Gu G, Wang Y, Wang D, Chen X, Yang Y, He D, Xin T^#. KPNA2 promotes metabolic reprogramming in glioblastomas by regulation of c-myc. J Exp Clin Cancer Res. 2018 Aug 16;37(1):194. 

8.Han M, Yang H, Lu X, Li Y, Liu Z, Li F, Shang Z, Wang X, Li X, Li J, Liu H^#, Xin T^#. Three-Dimensional-Cultured MSC-Derived Exosome-Hydrogel Hybrid Microneedle Array Patch for Spinal Cord Repair. Nano Lett. 2022 Aug 10;22(15):6391-6401. 

9.Wang Z, Liu Z, Wang S, Bing X, Ji X, He D, Han M, Wei Y, Wang C, Xia Q, Yang J, Gao J, Yin X, Wang Z, Shang Z, Xu J, Xin T^#, Liu Q. Implantation of hydrogel-liposome nanoplatform inhibits glioblastoma relapse by inducing ferroptosis. Asian J Pharm Sci. 2023 May;18(3):100800. 

10.Wang X, Chen M, Shen Y, Li Y, Li S, Xu Y, Liu Y, Su F, Xin T^#. A longitudinal electrophysiological and behavior dataset for PD rat in response to deep brain stimulation. Sci Data. 2024 May 15;11(1):500.