个人简介：

医学博士，教授。主要研究工作旨在探究肝脏稳态平衡中的表观遗传学调控机制，以转录调控因子为分子靶点深入挖掘其在肝脏不同组分细胞中的功能。通过阐明细胞-细胞间对话以及胞外-胞内信号转导机制，探究其在肝脏疾病中发挥重要调控作用。近五年内围绕肝脏纤维化、非酒精性脂肪性肝炎及肝脏再生等研究方向在Gut、Hepatology、Adv Sci、Acta Pharm Sin B、Redox Biol等国际期刊以第一作者或通讯作者身份发表SCI研究论文二十余篇，其中一区12篇，累计影响因子＞180。曾担任江苏省病理生理学会青年工作委员会副主任委员、Life Sciences杂志特刊编辑。主持国家自然科学基金青年基金项目及省自然科学基金青年基金项目各一项。研究成果获2021年省科学技术奖（自然科学）一等奖一项（排3，3/7）。

主要研究领域：

肝脏损伤与修复及其相关转录调控机制

代表性论文：

     1. Kong M, Kang AQ, Xu HH, Li M, Miao XL, Guo Y, Li ZL*, Xu Y*. The histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis. Gut. 2024 Jan 4:gutjnl-2023-329671. (IF = 24.5)

        2. Zhou JW#, Sun XY#, Liu HM, Chen XL, Miao XL, Guo Y, Fan ZW, Li J*, Xu Y*, Li ZL*. Phosphatidic acid-enabled MKL1 contributes to liver regeneration: translational implication in liver failure. Acta Pharm Sin B. 2024 Jan;14(1):256-272. (IF = 14.5)

        3. Fan ZW#, Sun XY#, Chen XL, Liu HM, Miao XL, Guo Y, Xu Y, Li J*, Zou XP*, Li ZL*. C-C motif chemokine CCL11 is a novel regulator and a potential therapeutic target in non-alcoholic fatty liver disease. JHEP Rep. 2023 Sept; 5(9): 100805. (IF = 8.3)

        4. Kong M#, Dong WH#, Kang AQ, Kuai YM, Xu TC, Fan ZW, Shi LQ, Sun DL, Lu YJ*, Li ZL*, Xu Y*. Regulatory role and translational potential of CCL11 in liver fibrosis. Hepatology. 2023 Jul 1;78(1):120-135. (IF = 14)

        5. Sun XY#, Wang S#, Miao XL#, Zeng S#, Guo Y, Zhou AQ, Chen Y, Chen YF, Lv FQ, Fan ZW, Wang YT*, Xu Y*, Li ZL*. TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response. Cell Death Dis. 2023 Jun 24;14(6):372. (IF = 9)

        6. Guo Y#, Miao XL#, Sun XY#, Li LY, Zhou AQ, Zhu X, Xu Y, Wang QH, Li ZL*, Fan ZW*. Zinc finger transcription factor Egr1 promotes non-alcoholic fatty liver disease. JHEP Rep. 2023 May 1;5(6):100724. (IF = 8.3)

        7. Li N, Liu H, Xue YJ, Xu Z, Miao XL, Guo Y, Li ZL*, Fan ZW*, Xu Y*. Targetable Brg1-CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking. EMBO Mol Med. 2023 Mar 8;15(3): e16592. (IF = 11.1)

        8. Dong WH, Kong M, Liu H, Xue YJ, Li ZL*, Wang YT*, Xu Y*. Myocardin-related transcription factor A drives ROS-fueled expansion of hepatic stellate cells by regulating p38-MAPK signalling. Clin Transl Med. 2022 Feb;12(2): e688. (IF = 10.6)

        9. Kong M#, Dong WH#, Zhu YW, Fan ZW, Miao XL, Guo Y, Li CP, Duan YF, Lu YJ*, Li ZL*, Xu Y*. Redox-sensitive activation of CCL7 by BRG1 in hepatocytes during liver injury. Redox Biol. 2021 Oct; 46:102079. (IF = 11.8)

       10. Li ZL#, Lu YJ#, Zhao QW#, Zhang YX, Li LY, Li M, Chen XM, Sun DL, Duan YF*, Xu Y*. DDIT4 S-nitrosylation aids p38-MAPK signaling complex assembly to promote hepatic ROS production. Adv Sci.2021 Sept 22; 8(18):2101957. (IF = 16.8)

招生招聘：

欢迎有肝脏领域科研兴趣的同学报考研究生，另诚招科研助理一名。

联系方式：

zlli@sdfmu.edu.cn