个人简介:
教授,研究员,博士生导师,国家“万人计划”青年拔尖和泰山学者青年专家获得者,任山东第一医科大学科研部副部长、脑科学与类脑研究院副院长、附属省立医院神经内科副主任医师。长期从事睡眠和认知障碍疾病的流行病、临床和基础的研究工作。近年来获得山东省科技进步奖二等奖2项,主持美国阿尔茨海默病协会临床科学家项目、中央军委科技委专项项目、国家自然科学基金面上项目和青年科学基金等多项省部级重大课题。以第一或通讯作者(含共同)累计发表SCI论文30余篇,包括Signal Transduct Target Ther (IF=39.3), Alzheimers Dement (IF=21.6), Nat Commun (IF=17.7), Am J Gastroenterol (IF=12.0)和EBioMedicine (IF=11.2)等专业内的一流杂志。兼任中国医师协会神经病学分会神经免疫学组委员、中国睡眠研究会睡眠与心理卫生专业委员会副总干事等。
主要研究领域:
1. 基于老年和大学生人群队列阐明睡眠和认知障碍疾病的流行病学特征、危险因素和干预策略;
2. 从基因-环境-脑老化交互作用的角度阐明睡眠和认知障碍疾病的发病机制和神经环路;
3. 抗神经系统疾病新型小分子药物设计、筛选、验证及新药先导化合物研究。
代表性论文:
1. Xiaoxing Liu#, Wandi Xiong#, Maosen Ye, Tangsheng Lu, Kai Yuan, Suhua Chang, Ying Han, Yongxiang Wang*, Lin Lu*, Yanping Bao*. Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets. Signal Transduct Target Ther. 2023 Dec 6;8(1):441. (影响因子40.8,共同通讯3/3);
2. Yongxiang Wang, Qi Han, Xiaolei Han, Yi Dong, Ming Mao, Chaoqun Wang, Xiaojie Wang, Shi Tang, Cuicui Liu, Yuanjing Li, Tingting Hou, Lin Cong, Yifeng Du*, Chengxuan Qiu*. Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study. Immun Ageing. 2023 Jul 25;20(1):36. (影响因子9.701,第一作者);
3. Qi Han#, Xiaolei Han#, Xiaojie Wang, Chaoqun Wang, Ming Mao, Shi Tang, Lin Cong, Tingting Hou, Cuicui Liu, Yongxiang Wang*, Yifeng Du*, Chengxuan Qiu. Association of accelerometer-measured sedentary behavior patterns with non-alcoholic fatty liver disease among older adults: the MIND-China study. Am J Gastroenterol. 2023;00:1-5.(影响因子12.045,共同通讯2/2);
4. Yi Dong, Yuanjing Li, Keke Liu, Xiaolei Han, Rui Liu, Yifei Ren, Lin Cong, Qinghua Zhang, Tingting Hou, Lin Song, Shi Tang, Lin Shi, Yishan Luo, Grégoria Kalpouzos, Erika J. Laukka, Bengt Winblad, Yongxiang Wang*, Yifeng Du*, Chengxuan Qiu. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimers Dement. 2022 Sep 15. (影响因子16.655,共同通讯2/2);
5. Xiaolei Han, Chaoqun Wang, Lin Song, Xiaojie Wang, Shi Tang, Tingting Hou, Cuicui Liu, Xiaoyan Liang, Chengxuan Qiu, Yongxiang Wang*, Yifeng Du*. KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion. EBioMedicine, 2022 Apr;78:103980. (影响因子11.205,共同通讯2/2);
6. Lin Song#, Shi Tang#, Xiaolei Han, Ziying Jiang, Lingling Dong, Cuicui Liu, Xiaoyan Liang, Qinghua Zhang, Xiaojuan Han, Lin Cong, Jixin Dong, Chengxuan Qiu, Yongxiang Wang*, Yifeng Du*. KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a. Nat Commun, 2019, Apr 9;10(1):1639. (影响因子17.694,共同通讯2/2)。
招生招聘:
招聘神经科学、临床医学、基础医学、公共卫生等相关背景的骨干人才、博士后、研究生和科研助理,待遇从优。
联系方式:
wangyongxiang@sdfmu.edu.cn