导师介绍：
邹桂昌，教授，博士生导师，山东第一医科大学科研部副部长，山东省优青，泰山学者青年专家，山东省高等学校“青创团队”带头人，山东第一医科大学高层次拔尖人才。2018年博士毕业于中国科学技术大学。2023年入职山东第一医科大学脑科学与类脑研究院。获中国科学院朱李月华奖和张锡钧优秀论文奖。长期从事神经精神疾病如物质成瘾、睡眠障碍和神经退行性疾病等的分子神经环路机制研究及新型药物研发工作。前期研究成果以第一/通讯作者(含共同)发表在Nature Metabolism、Science Advances、Nature Communications、Molecular Psychiatry、PNAS、Cell Reports等国际知名期刊，并获得多项权威杂志、综述文章的引用以及Science Advances、Trends in Molecular Medicine、《New Scientist》等杂志的专题评述。获国家自然科学基金专项项目，面上项目（临床专项）和青年基金项目及多项省部级项目的资助。
主要研究领域:
l 精神活性物质如大麻和酒精调控负性情绪和社会行为的神经环路及分子机制
l 精神活性物质调控AD、药物成瘾和睡眠障碍等神经精神疾病的机制研究
l 新型小分子药物设计、筛选与研发
代表性论文:
1. Guichang Zou#, Jing Xia#, Heyi Luo, Dan Xiao, Jin Jin, Chenjian Miao, Xin Zuo, Qianqian Gao, Zhi Zhang, Tian Xue, Yezi You, Ye Zhang, Li Zhang and Wei Xiong*. Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells. Nature Metabolism, 2022, 4: 1138–1149.
2. Jin Jin#, Chonglei Fu#, Jing Xia#, Heyi Luo#, Xianglian Wang, Si Chen, Huanhuan Mao, Kai Yuan, Lin Lu*, Wei Xiong* and Guichang Zou*. Cannabidiol ameliorates cognitive decline in 5×FAD mouse model of Alzheimer's disease through potentiating the function of extrasynaptic glycine receptors, Molecular Psychiatry, 2024, doi: 10.1038/s41380-024- 02789-x.
3. Guichang Zou#, Xin Zuo#, Kai Chen, Yushu Ge, Xiaoqun Wang, Guangwei Xu, Huan Wang, Chenjian Miao, Zhenyu Xu, Shuangshuang Tian, Zhen Wang, Yifeng Zhou, Wei Wei, Guangming Huang, Dan Liu and Wei Xiong*. Cannabinoids Rescue Cocaine-induced Seizure by Restoring Brain Glycine Receptor Dysfunction. Cell Reports, 2020, 30 (12): 4209-4219.
4. Yiwen Hou#, Guichang Zou#, Xianglian Wang, Hui Guo, Xiao Ma, Xingyu Cheng, Zhiyong Xie, Xin Zuo, Jing Xia, Huanhuan Mao, Man Yuan, Qi Chen, Peng Cao, Yupeng Yang, Li Zhang, Wei Xiong*. Coordinated activity of a central pathway drives associative opioid analgesic tolerance. Science Advances, 2023, doi:10.1126/sciadv.abo5627.
5. Jin Ye#, Guichang Zou#, Ruichi Zhu, Chao Kong, Chenjian Miao, MingjieZhang, Jianchao Li*, Wei Xiong*, and Chao Wang*. Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission. Nature Communications, 2021,12: 297.
6. Hongying Zhu#, Guichang Zou#, Ning Wang#, Meihui Zhuang, Wei Xiong* & Guangming Huang*. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry. PNAS, 2017, 114: 2586-2591.
7. Jing Xia#, Dan Xiao#, Heyi Luo1, Jin Jin, Siyuan Ge, Xianglian Wang, Guichang Zou*, Wei Xiong*. Cannabinoid Suppresses Neuropathic Pain by Utilizing Spinal Glycine Receptor-mediated Compensation. J Biol Chem, 2023, 6:104769.
8. Guichang Zou, Qi Chen, Kai Chen, Xin Zuo, Yushu Ge, Yiwen Hou, Tao Pan, Huilin Pan, Dan Liu, Li Zhang, Wei Xiong*. Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABAA Receptors. iScience, 2019, 19: 634-646 (Featured Content)
9. Guichang Zou, Jing Xia, Qianqian Han, Dan Liu, and Wei Xiong*. The synthetic cannabinoid dehydroxylcannabidiol restores the function of a major GABAA receptor isoform in a cell model of hyperekplexia. J Biol Chem, 2020, 295: 138-145
10. Yujun Guo#, Guichang Zou#, Keke Qi, Jin Jin, Lei Yao, Yang Pan and Wei Xiong*. Simvastatin Impairs Hippocampal Synaptic Plasticity and Cognitive Function in Mice. Mol Brain, 2021, 14: 41
11. Jieping Lu#, Sijia Fan#,Guichang Zou, Yiwen Hou, Tao Pan, Weiwei Guo, Lei Yao, Feng Du, GE Homanics, Dan Liu, Li Zhang, Wei Xiong*. Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia. Neuropharmacology, 2018, 133: 224-232
12. Mengyun Dou#, Zhenxiao Ma#, Xueying Cheng, Guichang Zou, Yan Xu, Cheng Huang, Wei Xiong, Shufang He*, Ye zhang*. Intrathecal lentivirus-mediated RNA interference targeting nerve growth factor attenuates myocardial ischaemia–reperfusion injury in rat. British Journal of Anaesthesia, 2019, 123(4):439-449
13. 邹桂昌,熊伟,刘光慧,李梢,张国林,刘峰,陈彪,黎健,松阳洲,朱元贵,孙瑞娟,申勇.中国器官衰老与器官退行性变化的机制研究进展[J].中国科学通报, 2023, 68(20): 2594-2605.
招生招聘：
实验室招聘神经生物学或分子生物学等相关背景的副教授、博士后和实验员，待遇从优。同时欢迎本科实习生和报考研究生。
联系方式：
guicz@sdfmu.edu.cn
