姓名：唐吉友
职称：主任医师
主要研究领域：研究orexin系统在睡眠剥夺所致学习记忆损害中的机制以及延缓阿尔茨海默病进展的干预研究。在睡眠评估的基础上，利用多导睡眠检测、影像学以及事件相关电位评估失眠障碍、中枢性嗜睡患者的记忆、注意力等认知域，同时分析睡眠障碍状态下脑功能网络变化，旨在探索睡眠-觉醒障碍发病机制及干预睡眠对认知功能的影响，为阿尔兹海默病等痴呆早期治疗提供新的策略。
代表性论文：
1. Baokun Zhang, Shanshan Lu, Huiying Guo, Juanjuan Xu, Zhang Xiao, Hongyao Zhao, Jiyou Tang*. The effect of obstructive sleep apnea on fatty liver disease may be obscured by alcohol consumption: An ordinal logistic regression analysis. Sleep Med. 2023; 109:82-89.
2. Baokun Zhang, Shanshan Lu, Huiying Guo, Juanjuan Xu, Zhang Xiao, Jiyou Tang*. Relationship between ODI and sleep structure of obstructive sleep apnea and cardiac remodeling. Sleep Breath. 2023;10.1007/s11325-023-02872-7.
3. Xu F*, Zhao J, Liu M, Yu X, Wang C, Lou Y, Shi W, Liu Y, Gao L, Yang Q, Zhang B, Lu S*, Tang J*, Leng J*. Exploration of sleep function connection and classification strategies based on sub-period sleep stages. Front Neurosci. 2023; 16:1088116. Published 2023 Jan 25.
4. Zhou M, Tang J*, Li S, Li Y, Zhao M. Orexin dual receptor antagonists, zolpidem, zopiclone, eszopiclone, and cognitive research: A comprehensive dose-response meta-analysis. Front Hum Neurosci. 2023; 16:1029554. Published 2023 Jan 9.
5. Lu S#, Song L#, Wang D, Zhang X, Lv X, Yin H, Gao Y, Liu X, Tang J*. White matter hyperintensity and cognitive impairments in chronic insomniacs. Neuroreport. 2019;30(9):612-618.
6. Tang S, Huang W, Lu S, Lu L, Li G, Chen X, Liu X, Lv X, Zhao Z, Duan R, Du Y, Tang J*. Increased plasma orexin-A levels in patients with insomnia disorder are not associated with prepro-orexin or orexin receptor gene polymorphisms. Peptides. 2017; 88:55-61.
7. Li G, Tang S, Chi H, Huang W, Lu S, Lv X, Liu X, Li Y, Wang Y, Tang J*. Orexin-A aggravates the impairment of hippocampal neurons caused by intermittent hypoxemia by the OXR-PLCβ1-ERK1/2 pathway. Neuroreport. 2017;28(6):331-338.
8. Liu X, Hou L, Huang W, Gao Y, Lv X and Tang J*. The Mechanism of Long Non-coding RNA MEG3 for Neurons Apoptosis Caused by Hypoxia: Mediated by miR-181b-12/15-LOX Signaling Pathway. Front Cell Neurosci. 2016;10:201.
9. Xuan Zhao; Rui xue Zhang; Shi Tang; Yan yan Ren; Wei xia Yang; Xiao minLiu; Ji you Tang*. Orexin-A-induced ERK1/2 activation reverses impaired spatial learning and memory in pentylenetetrazol-kindled rats via OX1R-mediated hippocampal neurogenesis. Peptides. 2014; 54: 140-147.
10. Jiyou Tang; Jing Chen; Manjunath Ramanjaneya; Anu Punn; Alex C. Conner; Harpal S. Randeva*. The signalling profile of recombinant human orexin-2 receptor. Cell Signal. 2008;20(9):1651-1661.
代表性科研项目：
1. 山东省自然基金项目：干预睡眠障碍对AD小鼠学习记忆的影响及分子和病理机制研究（2020-2023），10万
2. 国家自然基金（面上项目）：基于orexin-A信号转导特性探讨睡眠剥夺损害学习记忆的分子与细胞机制（批准号：81471345），资助经费：70万。
3. 山东省科技厅省自然基金项目: Orexin-2受体基因多态性与原发性睡眠障碍及苯二氮卓类催眠药物成瘾性的相关性研究（编号：ZR2012HM068），资助经费：6万。
联系方式: tangjy0920@126.com
